Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis
of the brain aging and diverse range of neurological diseases including Alzheimer's …

Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis
of the brain aging and diverse range of neurological diseases including Alzheimer's …

Cathepsin B (CatB), a cysteine protease derived from lysosomes, was initially thought to non-
selectively degrade proteins from phagocytosis and autophagy in lysosomes. However …

Microglia, the resident mononuclear phagocyte population in the brain, have long been
implicated in the pathology of neurodegenerative age-associated disorders. However …

Alzheimer's disease is a progressive neurodegenerative disease characterized by senile
plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells. Activated …

During normal aging, innate immunity progresses to a chronic state. However, how oxidative
stress and chronic neuroinflammation arise during aging remains unclear. In this study, we …

A group of proteases in the endosomal/lysosomal proteolytic system have been designated
as cathepsins, which is derived from the Greek term meaning “to digest”. Considering that …

Cathepsin B (CB) is a cysteine lysosomal protease implicated in a number of inflammatory
diseases. Although it is now evident that caspase‐1, an essential enzyme for maturation of …

Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by
loss in memory, cognition, and executive function and activities of daily living. AD …

Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …