Targeting autophagy in disease: recent advances in drug discovery
D Kim, HY Hwang, HJ Kwon - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction Small molecules targeting autophagy have been highly implicated as new
therapeutic agents to treat diseases of interest. With the increasing demand for autophagy …
therapeutic agents to treat diseases of interest. With the increasing demand for autophagy …
Ligand-based discovery of small molecules suppressing cancer cell proliferation via autophagic flux inhibition
L Liu, Z Tian, Y Zhang, P Liu, Z Xin, Y Zhao, Y Li… - Journal of Molecular …, 2020 - Springer
Autophagy is a conserved self-degradation system closely related to cancer progression.
Small molecule inhibitors of autophagy have proven to be efficient tools in cancer therapy …
Small molecule inhibitors of autophagy have proven to be efficient tools in cancer therapy …
Autophagy: a new pathway for traditional Chinese medicine.
CB Cui Bing, YJM Yu JinMei - 2018 - cabidigitallibrary.org
Autophagy is a major intracellular degradation pathway that sequesters multiple cytoplasmic
components, including accumulated proteins, damaged organelles, or invading micro …
components, including accumulated proteins, damaged organelles, or invading micro …
Autophagy and its potent modulators from phytochemicals in cancer treatment
CY Sun, QY Zhang, GJ Zheng, B Feng - Cancer chemotherapy and …, 2019 - Springer
Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …
Progress of autophagy screening systems
J Xie, XW Zhang, F Hua, ZW Hu - Yao xue xue bao= Acta …, 2016 - europepmc.org
Autophagy is an active research area in the biomedical field as its role has been identified in
many physiological and pathological processes. Accordingly, there is a growing demand to …
many physiological and pathological processes. Accordingly, there is a growing demand to …
Targeting autophagy with small-molecule activators for potential therapeutic purposes
Z Fan, LX Wan, W Jiang, B Liu, D Wu - European Journal of Medicinal …, 2023 - Elsevier
Autophagy is well-known to be a lysosome-mediated catabolic process for maintaining
cellular and organismal homeostasis, which has been established with many links to a …
cellular and organismal homeostasis, which has been established with many links to a …
Incomplete autophagy: Trouble is a friend
Q Zhang, S Cao, F Qiu, N Kang - Medicinal Research Reviews, 2022 - Wiley Online Library
Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules
and organelles in which accumulated autophagosomes do not fuse with lysosomes for …
and organelles in which accumulated autophagosomes do not fuse with lysosomes for …
Natural product regulates autophagy in cancer
Y Xiaokaiti, X Li - Autophagy: Biology and Diseases: Clinical Science, 2020 - Springer
Anti-cancer effect of natural products has been widely known. As a sort of multi-target anti-
cancer agents, natural compound's regulation on autophagy in cancer cells has been …
cancer agents, natural compound's regulation on autophagy in cancer cells has been …
Autophagy-regulating small molecules and their therapeutic applications
KH Baek, J Park, I Shin - Chemical Society Reviews, 2012 - pubs.rsc.org
Autophagy or self-eating is a complicated cellular process that is involved in protein and
organelle digestion occurring via a lysosome-dependent pathway. This process is of great …
organelle digestion occurring via a lysosome-dependent pathway. This process is of great …
[引用][C] Autophagy modulation
C Harrison - Nature Reviews Drug Discovery, 2012 - go.gale.com
Autophagy is a lysosomal degradation pathway that controls the quality of the cytoplasm by
eliminating protein aggregates and damaged organelles. It is also involved in metabolic …
eliminating protein aggregates and damaged organelles. It is also involved in metabolic …