Autophagic compound database: a resource connecting autophagy‐modulating compounds, their potential targets and relevant diseases

Y Deng, L Zhu, H Cai, G Wang, B Liu - Cell Proliferation, 2018 - Wiley Online Library
Objectives Autophagy, a highly conserved lysosomal degradation process in eukaryotic
cells, can digest long‐lived proteins and damaged organelles through vesicular trafficking …

[HTML][HTML] Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Autophagy: a druggable process

E Morel, M Mehrpour, J Botti, N Dupont… - Annual Review of …, 2017 - annualreviews.org
Macroautophagy (hereafter called autophagy) is a vacuolar, lysosomal pathway for
catabolism of intracellular material that is conserved among eukaryotic cells. Autophagy …

Therapeutic targeting of autophagy in disease: biology and pharmacology

Y Cheng, X Ren, WN Hait, JM Yang - Pharmacological reviews, 2013 - ASPET
Autophagy, a process of self-digestion of the cytoplasm and organelles through which
cellular components are recycled for reuse or energy production, is an evolutionarily …

[HTML][HTML] Novel cancer treatments based on autophagy modulation

M Cordani, Á Somoza, M Tafani, I Dando… - Frontiers in …, 2021 - frontiersin.org
Autophagy is an intracellular process in response to stimulus by which damaged organelles,
protein aggregates, or invading pathogens, are targeted from autophagic vesicles to …

[PDF][PDF] Autophagy by natural products in cancer cells

T Efferth, G HJ - Biochem Anal Biochem, 2012 - m.23michael.com
The physiological function of autophagy in normal cells is to maintain cellular homeostasis
in nutrient-deprived states. The degradation of cytoplasmic material serves cell-autonomous …

Targeting autophagy in disease: established and new strategies

M Kocak, S Ezazi Erdi, G Jorba, I Maestro, J Farrés… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …

Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy

J Zhang, G Wang, Y Zhou, Y Chen, L Ouyang… - Cellular and Molecular …, 2018 - Springer
Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the
clearance of damaged or superfluous proteins and organelles. Accumulating studies have …

[HTML][HTML] New potential pharmacological functions of Chinese herbal medicines via regulation of autophagy

BYK Law, SWF Mok, AG Wu, CWK Lam, MXY Yu… - Molecules, 2016 - mdpi.com
Autophagy is a universal catabolic cellular process for quality control of cytoplasm and
maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus …

[HTML][HTML] Inhibiting cytoprotective autophagy in cancer therapy: an update on pharmacological small-molecule compounds

L Zhang, Y Zhu, J Zhang, L Zhang… - Frontiers in Pharmacology, 2022 - frontiersin.org
Autophagy is a self-degradation process in which damaged proteins and organelles are
engulfed into autophagosomes for digestion and eventually recycled for cellular metabolism …