High throughput screening for drug discovery of autophagy modulators
Autophagy is an evolutionally conserved process in cells for cleaning abnormal proteins and
organelles in a lysosome dependent manner. Growing studies have shown that defects or …
organelles in a lysosome dependent manner. Growing studies have shown that defects or …
Autophagy and Cancer Drug Discovery
Autophagy is a highly conserved lysosomal degradation pathway that is important for
maintaining cellular homeostasis by degrading bulk cytoplasm and superfluous or damaged …
maintaining cellular homeostasis by degrading bulk cytoplasm and superfluous or damaged …
[HTML][HTML] Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells
Resistance of cancer cells to chemotherapy is a significant problem in oncology and the
development of sensitising agents or small-molecules with new mechanisms of action to kill …
development of sensitising agents or small-molecules with new mechanisms of action to kill …
Autophagy in cancer: regulation by small molecules
AS Limpert, LJ Lambert, NA Bakas, N Bata… - Trends in …, 2018 - cell.com
During times of stress, autophagy is a cellular process that enables cells to reclaim
damaged components by a controlled recycling pathway. This mechanism for cellular …
damaged components by a controlled recycling pathway. This mechanism for cellular …
Small‐molecule regulators of autophagy and their potential therapeutic applications
M Zhou, R Wang - ChemMedChem, 2013 - Wiley Online Library
Autophagy is a highly conserved process in which damaged proteins and organelles are
sequestered in double‐membrane autophagosomes and delivered to lysosomes for …
sequestered in double‐membrane autophagosomes and delivered to lysosomes for …
Following autophagy step by step
J Terje, H Tom - 2011 - agris.fao.org
Autophagy is an evolutionarily conserved lysosomal degradation route for soluble
components of the cytosol and organelles. There is great interest in identifying compounds …
components of the cytosol and organelles. There is great interest in identifying compounds …
[HTML][HTML] Following autophagy step by step
TE Hansen, T Johansen - BMC biology, 2011 - Springer
Autophagy is an evolutionarily conserved lysosomal degradation route for soluble
components of the cytosol and organelles. There is great interest in identifying compounds …
components of the cytosol and organelles. There is great interest in identifying compounds …
[HTML][HTML] New visions on natural products and cancer therapy: autophagy and related regulatory pathways
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …
paying attention to medicinal applications of natural products. There are several …
[PDF][PDF] Autophagy, a new target for disease treatment
F Xie, LF Li, LX Chen - Science China. Life Sciences, 2013 - core.ac.uk
Since Ashford and Porter first discovered that cells “eat themselves” in 1962, the process
known as autophagy has generated intense interest in both biomedical research and clinical …
known as autophagy has generated intense interest in both biomedical research and clinical …
Discovery of small molecules that target autophagy for cancer treatment
Autophagy is a self-renewal process in cells by recycling redundant materials through
lysosomal machinery. The basal level of autophagy in eukaryotic cells plays a …
lysosomal machinery. The basal level of autophagy in eukaryotic cells plays a …