Chemical autophagy regulators

YP Yang, F Wang, CF Liu - Autophagy: Biology and Diseases: Technology …, 2021 - Springer
Autophagy is a catabolic process that removes aggregated proteins and damaged
organelles via lysosomal degradation. Increasing evidence suggests that dysfunction of …

Choose delicately and reuse adequately: the newly revealed process of autophagy

S Kobayashi - Biological and Pharmaceutical Bulletin, 2015 - jstage.jst.go.jp
Autophagy is a degradation system for intracellular components. One of the roles of
autophagy is the prompt removal of damaged organelles. Another unique role is to supply …

Targeting autophagy drug discovery: Targets, indications and development trends

M Jiang, W Wu, Z Xiong, X Yu, Z Ye, Z Wu - European Journal of Medicinal …, 2024 - Elsevier
Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …

Autophagy modulators from traditional Chinese medicine: Mechanisms and therapeutic potentials for cancer and neurodegenerative diseases

SF Wang, MY Wu, CZ Cai, M Li, JH Lu - Journal of ethnopharmacology, 2016 - Elsevier
Abstract Ethnopharmacological relevance Traditional Chinese medicine (TCM), an ancient
yet still alive medicinal system widely used in East Asia, has played an essential role in …

Novel pharmacological modulators of autophagy and therapeutic prospects

P Bischoff, E Josset, FJ Dumont - Expert opinion on therapeutic …, 2012 - Taylor & Francis
Introduction: Autophagy is an intracellular process of self-digestion involving the lysosomal
degradation of cytoplasmic organelles and macromolecules. It occurs at low basal levels to …

Chemical modulators of autophagy as biological probes and potential therapeutics

A Fleming, T Noda, T Yoshimori… - Nature chemical …, 2011 - nature.com
Autophagy is an evolutionarily conserved mechanism for protein degradation that is critical
for the maintenance of homeostasis in man. Autophagy has unexpected pleiotropic functions …

Natural autophagy regulators in cancer therapy: a review

Q Ding, J Bao, W Zhao, Y Hu, J Lu, X Chen - Phytochemistry Reviews, 2015 - Springer
Autophagy is a complicated self-eating response of cells to external or internal stimuli. This
process involves cellular degradation through the lysosomes of dysfunctional or …

[HTML][HTML] Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies

W Ma, Y Lu, X Jin, N Lin, L Zhang, Y Song - Journal of Advanced Research, 2024 - Elsevier
Background Autophagy is an evolutionarily conserved turnover process for intracellular
substances in eukaryotes, relying on lysosomal (in animals) or vacuolar (in yeast and plants) …

[HTML][HTML] Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity

MY Wu, SF Wang, CZ Cai, JQ Tan, M Li, JJ Lu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Autophagy is a cellular bulk degradation pathway implicated in various diseases. Inhibition
of autophagy has been regarded as a new therapeutic strategy for cancer treatment …

Autophagy modulators from traditional Chinese medicine: mechanisms and therapeutic potentials for cancer and neurodegenerative diseases.

WSF Wang ShengFang, WMY Wu MingYue… - 2016 - cabidigitallibrary.org
Abstract Ethnopharmacological relevance: Traditional Chinese medicine (TCM), an ancient
yet still alive medicinal system widely used in East Asia, has played an essential role in …