Autophagy inhibitors

B Pasquier - Cellular and Molecular Life Sciences, 2016 - Springer
Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular
and molecular mechanisms underlying this process are highly complex and involve multiple …

Research progress of the role of autophagy in alzheimer's disease and drug intervention

R WANG - Chinese Pharmaceutical Journal, 2015 - pesquisa.bvsalud.org
Autophagy is a specific phenomenon of life which is widespread in eukaryotic cells and is
also a main cell metabolic pathway of long-lived proteins and cytoplasmic organelles …

Autophagy modulation as a potential therapeutic target for diverse diseases

DC Rubinsztein, P Codogno, B Levine - Nature reviews Drug discovery, 2012 - nature.com
Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …

[HTML][HTML] Targeting autophagy-related protein kinases for potential therapeutic purpose

H Xiang, J Zhang, C Lin, L Zhang, B Liu… - … Pharmaceutica Sinica B, 2020 - Elsevier
Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Targeting autophagy to overcome human diseases

M Condello, E Pellegrini, M Caraglia… - International journal of …, 2019 - mdpi.com
Autophagy is an evolutionarily conserved cellular process, through which damaged
organelles and superfluous proteins are degraded, for maintaining the correct cellular …

Herbal Drugs Inducing Autophagy for the Management of Cancer: Mechanism and Utilization

S Rajput, PK Sharma, R Malviya - Current Pharmaceutical …, 2024 - ingentaconnect.com
When compared to chemical medicines, herbal medicines have the greatest therapeutic
benefit while having fewer harmful side effects. Many different components in herbs have an …

Natural autophagy regulators in cancer therapy: a review.

DQ Ding Qian, BJL Bao JiaoLin, ZWW Zhao WenWen… - 2015 - cabidigitallibrary.org
Autophagy is a complicated self-eating response of cells to external or internal stimuli. This
process involves cellular degradation through the lysosomes of dysfunctional or …

Small-Molecule Regulators of Autophagy as Potential Anti-cancer Therapy

Q Li, M Zhou, R Wang - Targeting Autophagy in Cancer Therapy, 2016 - Springer
Autophagy is an evolutionary conserved lysosomal pathway functioned in the turnover of
cellular macromolecules and organelles. It is known that autophagy can have a …

Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine

J ZHU, G SHANG, J ZHANG, H SUN… - Chinese Journal of …, 2019 - pesquisa.bvsalud.org
The cure of tumors is a difficulty in the world, and both the quality of life and the survival rate
of patients remain low. Therefore, it is very meaningful to find a drug target to inhibit the …