Although the diverse triggers of AD are still under debate, the hypothesis of the contribution
of cerebrovascular deficiencies has emerged in recent years. Cerebrovascular dysfunction …

Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

Alzheimer's disease (AD) and cerebrovascular diseases share common vascular risk factors
that have disastrous effects on cerebrovascular regulation. Endothelial cells, lining inner …

Transgenic mice overexpressing the amyloid precursor protein (APP) have a profound
impairment in endothelium-dependent cerebrovascular responses that is counteracted by …

Vascular wall levels of soluble β-amyloid1–40 (Aβ1–40) are elevated in Alzheimer's disease
(AD). Moreover, plasma Aβ levels are increased in familial AD, as well as in some cases of …

Abnormal accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of
Alzheimer's disease (AD). In addition to neurotoxic effects, Aβ also damages brain …

Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

Alzheimer's disease (AD) has been recently associated with vascular risk factors. β-amyloid
peptides (AβP), the main component of senile plaques typical of AD, circulate in soluble …

Background and Purpose—Amyloid-β (Aβ), a peptide that accumulates in the brain and
circulates in the blood of patients with Alzheimer disease, alters the regulation of cerebral …

Amyloid beta (Aβ), a peptide family produced and deposited in neurons and endothelial
cells (EC), is found at subnanomolar concentrations in the plasma of healthy individuals …