Background Silicosis is a severe pulmonary disease caused by inhaling dust containing
crystalline silica. The progression of silicosis to pulmonary fibrosis is usually unavoidable …

Background Inhalation of dust containing silica particles is associated with severe
pulmonary inflammation and lung injury leading to chronic silicosis including fibrotic …

Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

Silicosis is a disease characterized by extensive lung nodules and fibrosis caused by the
prolonged inhalation of silica in occupational settings. However, the molecular mechanism …

As a fatal occupational disease with limited therapeutic options, molecular mechanisms
underpinning silicosis are still undefined. Herein, single-cell RNA sequencing of the lung …

Silicosis is a fatal fibrotic lung disease caused by long-term silica particle exposure, in which
pulmonary macrophages play an important role. However, the relationship between …

The pathophysiology of silicosis is poorly understood, limiting development of therapies for
those who have been exposed to the respirable particle. We explored the mechanisms of …

Background: Lung fibrosis is characterized by fibroblast proliferation and collagen
deposition. CXC chemokine receptor 4 (CXCR4), which binds the stromal cell-derived factor …

Silicosis is a lethal pneumoconiosis disease characterized by chronic lung inflammation and
fibrosis. The present study was to explore the effect of against crystalline silica (CS)-induced …

Long term pulmonary exposure to crystalline silica leads to silicosis that manifests
progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite …