Mechanisms involved in myelin repair remyelination are poorly understood. This project
examined changes in oligodendrocyte function during remyelination in the adult central …

在多发性硬化症患者的中枢神经系统中, 脱髓鞘的轴突难以有效复髓鞘是治疗疾病的主要障碍,
而髓鞘再生失败的瓶颈问题是少突胶质细胞前体细胞 (OPC) 不能分化为成熟的少突胶质细胞 …

Demyelination occurs in response to brain injury and is observed in many
neurodegenerative diseases. Myelin is synthesized from oligodendrocytes in the central …

在多发性硬化症患者的中枢神经系统中， 脱髓鞘的轴突难以有效复髓鞘是治疗疾病的主要障碍，
而髓鞘再生失败的瓶颈问题是少突胶质细胞前体细胞（ OPC） 不能分化为成熟的少突胶质细胞 …

Central nervous system (CNS) regeneration is a subject of great interest, particularly in
diseases causing a dramatic loss of neurons. However, some CNS diseases do not affect …

Endogenous remyelination of the CNS can be robust and restore function, yet in multiple
sclerosis it becomes less complete with time. Promoting remyelination is a major therapeutic …

Demyelination in the adult CNS can be followed by extensive repair. However, in multiple
sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions …

NAtuRe Reviews| Neurology Previously unseen oligodendrocyte dynamics and
heterogeneity could limit remyelination in multiple sclerosis (MS), according to two new …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

Demyelinating disorders of the central nervous system are among the most crippling
neurological diseases affecting patients at various stages of life. In the most prominent …