[HTML][HTML] Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

R Yang, J Pan, Y Wang, P Xia, M Tai… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …

[HTML][HTML] Improving Efficiency of Direct Pro-Neural Reprogramming: Much-Needed Aid for Neuroregeneration in Spinal Cord Injury

DA Chudakova, EM Samoilova, VP Chekhonin… - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a medical condition affecting~ 2.5–4 million people worldwide.
The conventional therapy for SCI fails to restore the lost spinal cord functions; thus, novel …

Cellular transplantation-based evolving treatment options in spinal cord injury

M Wu, H Yuan, K Li, DL Qiu - Cell biochemistry and biophysics, 2015 - Springer
Spinal cord injury (SCI) often represents a condition of permanent neurologic deficit. It has
been possible to understand and delineate the mechanisms contributing to loss of function …

Current status of cell-mediated regenerative therapies for human spinal cord injury

T Zhu, Q Tang, H Gao, Y Shen, L Chen, J Zhu - Neuroscience bulletin, 2014 - Springer
During the past decade, significant advances have been made in refinements for
regenerative therapies following human spinal cord injury (SCI). Positive results have been …

[HTML][HTML] Neuronal reprogramming in treating spinal cord injury

X Chen, H Li - Neural regeneration research, 2022 - journals.lww.com
Spinal cord injury represents a devastating central nervous system injury that could impair
the mobility and sensory function of afflicted patients. The hallmarks of spinal cord injury …

Cell-based transplantation strategies to promote plasticity following spinal cord injury

CA Ruff, JT Wilcox, MG Fehlings - Experimental neurology, 2012 - Elsevier
Cell transplantation therapy holds potential for repair and functional plasticity following
spinal cord injury (SCI). Stem and progenitor cells are capable of modifying the lesion …

Therapeutical strategies for spinal cord injury and a promising autologous astrocyte-based therapy using efficient reprogramming techniques

H Yang, C Liu, CY Wang, Q Zhang, J An, L Zhang… - Molecular …, 2016 - Springer
Spinal cord injury (SCI) is a traumatic event resulting in disturbances to normal sensory,
motor, or autonomic functions, which ultimately impacts a patient's physical, psychological …

In vivo cell fate reprogramming for spinal cord repair

W Tai, CL Zhang - Current opinion in genetics & development, 2023 - Elsevier
Spinal cord injury (SCI) can lead to the loss of motor, sensory, or autonomic function due to
neuronal death. Unfortunately, the adult mammalian spinal cord has limited intrinsic …

[HTML][HTML] A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation

YM Fang, WC Chen, WJ Zheng, YS Yang… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury causes varying degrees of motor and sensory function loss. However,
there are no effective treatments for spinal cord repair following an injury. Moreover …

Gene-modified stem cells for spinal cord injury: A promising better alternative therapy

Y Feng, Y Li, PP Shen, B Wang - Stem Cell Reviews and Reports, 2022 - Springer
Stem cell therapy holds great promise for the treatment of spinal cord injury (SCI), which can
reverse neurodegeneration and promote tissue regeneration via its pluripotency and ability …