移植后间充质基质细胞与免疫系统之间的相互作用: 对视网膜细胞高级治疗的意义

M Norte-Muñoz, D García-Bernal… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are
widely investigated in preclinical models. Mesenchymal stromal cells are well positioned as …

Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina

M Norte-Muñoz, D García-Bernal… - Neural Regeneration …, 2023 - journals.lww.com
Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are
widely investigated in preclinical models. Mesenchymal stromal cells are well positioned as …

Effect of the transplantation type on the neuroprotective properties of mesenchymal stromal cells

M Norte‐Muñoz, D García‐Bernal… - Acta …, 2024 - Wiley Online Library
Many preclinical studies using adult Mesenchymal Stromal Cells (MSCs) for
neurodegenerative diseases show promising results. However, there is a lack of …

[HTML][HTML] Immune recognition of syngeneic, allogeneic and xenogeneic stromal cell transplants in healthy retinas

M Norte-Muñoz, A Gallego-Ortega… - Stem cell research & …, 2022 - Springer
Background Advanced therapies using adult mesenchymal stromal cells (MSCs) for
neurodegenerative diseases are not effectively translated into the clinic. The cross talk …

[HTML][HTML] Neuroprotection and axonal regeneration induced by bone marrow mesenchymal stromal cells depend on the type of transplant

M Norte-Muñoz, F Lucas-Ruiz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cell (MSC) therapy to treat neurodegenerative diseases has not been
as successful as expected in some preclinical studies. Because preclinical research is so …

[HTML][HTML] Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model

É Reboussin, J Buffault, F Brignole-Baudouin… - Journal of …, 2022 - Springer
Background Glaucoma is a blinding degenerative neuropathy in which the death of retinal
ganglion cells (RGCs) causes progressive loss of visual field and eventually vision …

Immunosuppressive activity of adult marrow mesenchymal stromal cells on innate immune cells in the central nervous system

MA Dao, JA Nolta, CC Case - Advances in Neuroimmune …, 2013 - content.iospress.com
Adult marrow derived mesenchymal stromal cells are currently in clinical trials for various
neurodegenerative diseases. Through secretion of soluble and insoluble trophic factors …

Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro

LC Teixeira-Pinheiro, MF Toledo… - Experimental Eye …, 2020 - Elsevier
Purpose Cellular therapy with mesenchymal stem cells (MSC) is emerging as an effective
option to treat optic neuropathies. In models of retinal degeneration, MSC injected in the …

Mesenchymal stem cells for the treatment of neurological diseases: Immunoregulation beyond neuroprotection

A Laroni, NK de Rosbo, A Uccelli - Immunology letters, 2015 - Elsevier
An inflammatory response is often observed in neurological diseases, being characterized
sometimes by activation of adaptive cells (T and B lymphocytes) and, almost inexorably, of …

[HTML][HTML] Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain

N De Vocht, D Lin, J Praet, C Hoornaert, K Reekmans… - Immunobiology, 2013 - Elsevier
Although cell transplantation is increasingly suggested to be beneficial for the treatment of
various neurodegenerative diseases, the therapeutic application of such intervention is …