Schisandra Inhibit Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Rats via Suppressing M2 Macrophage Polarization

Z Guo, S Li, N Zhang, Q Kang… - BioMed Research …, 2020 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause and limited to the lungs. Schisandrae …

Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis

M Xu, C Zhao, H Song, C Wang, H Li, X Qiu, H Jing… - Scientific Reports, 2023 - nature.com
Pulmonary fibrosis (PF) is a serious progressive fibrotic disease that is characterized by
excessive accumulation of extracellular matrix (ECM), thus resulting in stiff lung tissues …

Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through the wingless/integrase-1 signaling pathway

Y Wang, X Dong, N Zhao, X Su, Y Wang… - Experimental lung …, 2020 - Taylor & Francis
Abstract Purpose/Aim: Pulmonary fibrosis (PF) is characterized by the progressive and
ultimately fatal accumulation of fibroblasts and extracellular matrix in the lung that distorts its …

Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression …

D Zhang, B Liu, B Cao, F Wei, X Yu, G Li… - International …, 2017 - Elsevier
Pulmonary fibrosis, a progressive and lethal lung disease, is a major therapeutic challenge
for which new therapeutic strategies are warranted. Schisandrin B (Sch B) and Glycyrrhizic …

Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β

C Huang, X Wu, S Wang, W Wang, F Guo, Y Chen… - Chinese Medicine, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial
lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The …

Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 …

L Wang, M Shao, W Jiang, Y Huang - Tissue and Cell, 2022 - Elsevier
Background Pulmonary fibrosis (PF) is a difficult clinical condition with no effective treatment
and a high mortality rate. Patients usually die of respiratory failure. In the present, we …

Kurarinone attenuates BLM-induced pulmonary fibrosis via inhibiting TGF-β signaling pathways

SJ Park, T Kim, K Lee, MA Kang, HJ Jang… - International Journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a refractory interstitial lung disease for which there is
no effective treatment. Although the pathogenesis of IPF is not fully understood, TGF-β and …

An herbal product alleviates bleomycin-induced pulmonary fibrosis in mice via regulating NF-κB/TNF-α signaling in macrophages

F Jing, X Chen, J Xue, K Huang, F Xing, X Hu… - Frontiers in …, 2022 - frontiersin.org
Background and aim: Pro-inflammatory macrophages aggravated progress of pulmonary
fibrosis (PF) both in patients and animal models. Fuzheng Huayu (FZHY) formula, a Chinese …

Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

L Gao, H Tang, H He, J Liu, J Mao, H Ji… - Frontiers in …, 2015 - frontiersin.org
Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that
lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted …

Barbaloin attenuates pulmonary fibrosis through TGF-β1/Smads/p38 pathway

G Zhang, R Bai, J Huang, Y Gao, X Yun… - Journal of Pharmacy …, 2022 - academic.oup.com
Objectives Barbaloin is one of the main bioactive ingredients extracted from Aloe vera,
which has the property of protecting the lung from LPS-induced acute injury; however, the …