Despite extensive research over many decades, human breast cancer remains a major
worldwide health concern. Advances in pre-clinical and clinical research has led to …

Clinical and molecular similarities between canine mammary tumours and human breast
cancer have been described in recent decades. Clinically, the similarities are very strong …

Breast cancer is the most common malignancy in women. Basic and translational breast
cancer research relies heavily on experimental animal models. Ideally, such models for …

Purpose Relevant animal models of human breast cancer are currently needed, especially
for the aggressive triple-negative breast cancer subtype. Recent studies and our results …

Background Similar to human breast cancer mammary tumors of the female dog are
commonly associated with a fatal outcome due to the development of distant metastases …

Introduction Genomic variability limits the efficacy of breast cancer therapy. To simplify
thestudy of the molecular complexity of breast cancer, researchers have used …

Genomic and precision medicine research has afforded notable advances in human cancer
treatment, yet applicability to other species remains uncertain. Through whole-exome and …

Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in
translational oncology, as they share the same environmental risk factors, key histological …

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive
molecular and cellular research, the mortality rate remains high. Preclinical testing of new …

Simple Summary The current article provides an overview of the significance of using
various mouse and zebrafish models in cancer research. In addition, this review discusses …