Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort
AP Viggars, SB Wharton, JE Simpson, FE Matthews… - Neuroscience …, 2011 - Elsevier
Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to
Alzheimer-type pathology remains poorly defined. We have investigated the BBB in …
Alzheimer-type pathology remains poorly defined. We have investigated the BBB in …
Sex-related differences in regional blood–brain barrier integrity in non-demented elderly subjects
The role of the blood–brain barrier (BBB) breakdown has been recognized as being
important in Alzheimer's disease pathogenesis. We aimed to evaluate whether regional BBB …
important in Alzheimer's disease pathogenesis. We aimed to evaluate whether regional BBB …
Imaging the role of blood–brain barrier disruption in normal cognitive ageing
ICM Verheggen, JJA de Jong, MPJ van Boxtel… - Geroscience, 2020 - Springer
To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI …
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI …
Blood–brain barrier breakdown in relationship to Alzheimer and vascular disease
Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …
biomarker in human cognitive impairment. However, the relationship between BBB …
[HTML][HTML] Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype
S Janelidze, J Hertze, K Nägga, K Nilsson… - Neurobiology of …, 2017 - Elsevier
Blood-brain barrier (BBB) dysfunction might be an important component of many
neurodegenerative disorders. In this study, we investigated its role in dementia using large …
neurodegenerative disorders. In this study, we investigated its role in dementia using large …
Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia
B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
Increase in blood–brain barrier leakage in healthy, older adults
ICM Verheggen, JJA de Jong, MPJ van Boxtel… - Geroscience, 2020 - Springer
Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …
Blood–brain barrier permeability in Alzheimer's disease: a case–control MRI study
JM Starr, AJ Farrall, P Armitage, B McGurn… - Psychiatry Research …, 2009 - Elsevier
Blood-brain barrier (BBB) dysfunction may contribute to the risk of Alzheimer's disease (AD).
Dynamic contrast-enhanced magnetic resonance imaging (MRI) was performed repeatedly …
Dynamic contrast-enhanced magnetic resonance imaging (MRI) was performed repeatedly …
Blood-cerebrospinal fluid barrier gradients in mild cognitive impairment and Alzheimer's disease: relationship to inflammatory cytokines and chemokines
Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier
(BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell …
(BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell …
Blood–brain barrier dysfunction as a cause and consequence of Alzheimer's disease
MA Erickson, WA Banks - Journal of Cerebral Blood Flow & …, 2013 - journals.sagepub.com
The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …