A stringent quality control process selects misfolded polypeptides generated in the
endoplasmic reticulum (ER) for ER-associated degradation (ERAD). Here we assessed the …

Proteins entering the secretory pathway are translocated across the endoplasmic reticulum
(ER) membrane in an unfolded form. In the ER they are restricted to a quality control system …

The endoplasmic reticulum (ER) maintains an environment essential for secretory protein
folding. Consequently, the premature transport of polypeptides would be harmful to the cell …

Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control.
Persistent association with ER-resident molecular chaperones prevents exit of misfolded or …

The internal environment of the eukaryotic cell is divided by membranes into various
organelles, containing diverse functional subcompartments, which allow complex cellular …

Terminally misfolded or unassembled secretory proteins are retained in the endoplasmic
reticulum (ER) and subsequently cleared by the ER-associated degradation (ERAD) …

Quality control in the endoplasmic reticulum ensures that only properly folded proteins are
retained in the cell through mechanisms that recognize and discard misfolded or …

The quality control mechanism in the endoplasmic reticulum (ER) discriminates correctly
folded proteins from misfolded polypeptides and determines their fate. Terminally misfolded …

Protein quality control in the endoplasmic reticulum (ER) is an elaborate process conserved
from yeast to mammals, ensuring that only newly synthesized proteins with correct …

The secretory pathway provides a physical route through which only correctly folded gene
products are delivered to the eukaryotic cell surface. The efficiency of endoplasmic reticulum …