Stroke is the second leading cause of mortality worldwide 1 and the third leading cause of
death in the United States. 2 Approximately 80% of strokes are ischemic in origin. Stroke …

Ischemic stroke is a leading cause of death worldwide, mainly in western countries. So far,
approved therapies rely on reperfusion of the affected brain area, by intravenous …

Cerebral ischemic stroke is one of the leading causes of death worldwide, carrying a
significant disease burden as the secondleading cause of disability-adjusted life years 1, 2 …

Every year, October 29th marks World Stroke Day (Sandercock, 2018). This initiative raises
awareness about stroke, the second leading cause of death worldwide and the third cause …

Stroke is a leading cause of serious long-term disability worldwide and the second leading
cause of death in many countries. Long-time attempts to salvage dying neurons via various …

Stroke seriously threatens human health because of its characteristics of high morbidity,
disability, recurrence, and mortality, thus representing a heavy financial and mental burden …

The first edition of this volume was well received by the stroke research community. In this
second edition, our international consortium of authors updated and expanded their …

Rodent models of ischemic stroke have been instrumental to study stroke pathophysiology,
but new models, more representative of the human condition, are needed to identify novel …

Mouse models of global cerebral ischemia are essential tools to study the molecular
mechanisms involved in ischemic brain damage. The availability of genetically engineered …

Therapeutic options available for acute stroke management are sparse and inadequate.
Therefore, new insights into stroke pathophysiology leading to new therapeutic targets are …