Breast cancer is not a single disease, but is instead a collection of diseases that have
distinct histopathological features, genetic and genomic variability, and diverse prognostic …

Introduction Genomic variability limits the efficacy of breast cancer therapy. To simplify
thestudy of the molecular complexity of breast cancer, researchers have used …

While animals have played a key role in scientific research for many years, there are limits to
the knowledge that can be gained through this model. Recently, alternatives to animal use …

Objective: To summarize the research status of the animal models of breast precancer.
Methods: A computer-based online search of Medline database and CHKD database was …

Literally thousands of specifically engineered mice have been created to study the
pathology, molecular biology, natural history and response to therapy in breast cancer. The …

Objective: Breast cancer is the second leading cause of death and the most common cancer
in women. With respect to a large number of limitations in human studies, there is the need …

Cancer is one of the most important public health problems worldwide. Despite the great
contribution of in-vitro studies for biomedical research, animals are essential to study …

Breast cancer is the most frequent spontaneous malignancy diagnosed in women and is
characterized by a broad histological diversity. Progression of the disease has a …

Human breast cancer is a heterogeneous disease with numerous subtypes that have been
defined through immunohistological, histological, and gene expression patterns. The …

Animal models refers to the animal experimental objects and related materials that can
simulate human body established in medical research. As the second-largest disease in …