A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-β1 pathway

KH Kim, S Lee, H Lee, D Shin, D Min, M Kim, B Ryu… - Scientific reports, 2018 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a devastating and common chronic lung disease
pathologically characterized by loss of epithelial cells and activation of fibroblasts and …

The efficacy of plant extract and bioactive compounds approaches in the treatment of pulmonary fibrosis: A systematic review

S Bahri, RB Ali, A Abidi, S Jameleddine - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Pulmonary fibrosis (PF) is a lethal, chronic and progressive respiratory disease leading to
interstitial lung damage and serious breathing problems. The pathogenic mechanism …

Natural product-based potential therapeutic interventions of pulmonary fibrosis

M Hasan, NC Paul, SK Paul, ASM Saikat, H Akter… - Molecules, 2022 - mdpi.com
Pulmonary fibrosis (PF) is a disease-refractive lung condition with an increased rate of
mortality. The potential factors causing PF include viral infections, radiation exposure, and …

Epigallocatechin gallate attenuates fibroblast proliferation and excessive collagen production by effectively intervening TGF‐β1 signalling

N Sriram, S Kalayarasan, R Manikandan… - Clinical and …, 2015 - Wiley Online Library
Pulmonary fibrosis (PF) poses a huge burden to the patients and society due to lack of an
effective treatment drug. Activation of fibrocyte, fibroblast and myofibroblasts are important …

Kangfuxin Oral Liquid Attenuates Bleomycin‐Induced Pulmonary Fibrosis via the TGF‐β1/Smad Pathway

H Yao, S Wei, Y Xiang, Z Wu, W Liu… - Evidence‐Based …, 2019 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease with a poor prognosis
characterized by transforming growth factor (TGF)‐β‐induced proliferation, migration, and …

Mefunidone ameliorates bleomycin-induced pulmonary fibrosis in mice

Y Han, M Jiang, R He, X Lv, X Liao, Y He… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial
lung diseases with poor prognosis. Currently, few effective drugs are available for IPF …

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

SA Hosseini, F Zahedipour, T Sathyapalan… - …, 2021 - Wiley Online Library
Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of
the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several …

Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 …

L Wang, M Shao, W Jiang, Y Huang - Tissue and Cell, 2022 - Elsevier
Background Pulmonary fibrosis (PF) is a difficult clinical condition with no effective treatment
and a high mortality rate. Patients usually die of respiratory failure. In the present, we …

Inhibiting TGF- 1-Mediated Cellular Processes as an Effective Strategy for the Treatment of Pulmonary Fibrosis with Chinese Herbal Medicines

J Wang, X Zhao, W Feng, Y Li… - The American Journal of …, 2021 - World Scientific
Pulmonary fibrosis (PF) is a chronic and irreversible interstitial lung disease that even
threatens the lives of some patients infected with COVID-19. PF is a multicellular …

Mimosa pudica L. extract ameliorates pulmonary fibrosis via modulation of MAPK signaling pathways and FOXO3 stabilization

QC Nguyen, HA Nguyen, TA Pham, VTH Tran… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Idiopathic pulmonary fibrosis (IPF) is a progressive
fibrosing pulmonary disorder that has a poor prognosis and high mortality. Although there …