[HTML][HTML] ATR 小分子抑制剂的研究进展
程浩东， 段云鑫， 施志浩 - Pharmacy Information, 2023 - hanspub.org
共济失调毛细血管扩张和Rad3 相关激酶(ATR) 是DNA 损伤反应(DDR) 的重要调节因子,
尤其是对复制压力(RS) 的反应. 由于DNA 损伤和RS 是基因组不稳定性的主要来源 …
尤其是对复制压力(RS) 的反应. 由于DNA 损伤和RS 是基因组不稳定性的主要来源 …
ATR 抑制剂抗肿瘤治疗的研究新进展
刘竹君， 刘东颖 - 中国肿瘤临床, 2023 - cjco.cn
DNA 损伤应答(DNA damage response, DDR) 机制包括检测DNA 损伤, 阻滞细胞周期和启动
DNA 修复. 共济失调毛细血管扩张和Rad3 相关激酶(ataxia telangiectasia and Rad3-related …
DNA 修复. 共济失调毛细血管扩张和Rad3 相关激酶(ataxia telangiectasia and Rad3-related …
[HTML][HTML] ATR 抑制剂抗肿瘤研究进展
赵志鹏， 陆涛， 焦宇 - Pharmacy Information, 2022 - hanspub.org
DNA 损伤反应(DDR) 机制负责检测DNA 损伤, 暂停细胞周期和启动DNA 修复.
共济失调毛细血管扩张和Rad3 相关蛋白(ATR) 是DDR 核心的关键激酶 …
共济失调毛细血管扩张和Rad3 相关蛋白(ATR) 是DDR 核心的关键激酶 …
M1774, a novel potent and selective ATR inhibitor, shows antitumor effects as monotherapy and in combination
A Zimmermann, H Dahmen, T Grombacher, U Pehl… - Cancer Research, 2022 - AACR
The protein kinase ataxia telangiectasia-mutated and Rad3-related (ATR) is an important
component of the DNA Damage Response (DDR) and a key mediator of the replication …
component of the DNA Damage Response (DDR) and a key mediator of the replication …
Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy
FT Zenke, A Zimmermann, H Dahmen, B Elenbaas… - Cancer Research, 2019 - AACR
The protein kinase ataxia telangiectasia mutated and Rad3-related ATR is one of the key
mediators of the DNA damage response. ATR is recruited to regions of single-stranded …
mediators of the DNA damage response. ATR is recruited to regions of single-stranded …
Discovery of 6, 7-dihydro-5H-pyrrolo [3, 4-d] pyrimidine derivatives as a new class of ATR inhibitors
P Chen, H Bin, Y Jiao, G Lin, Y Zhang, A Xia… - Bioorganic & Medicinal …, 2022 - Elsevier
Ataxia telangiectasia and Rad3-related (ATR) kinase is a key regulating protein within the
DNA damage response (DDR), responsible for sensing replication stress (RS), and has …
DNA damage response (DDR), responsible for sensing replication stress (RS), and has …
Targeting ATR in DNA damage response and cancer therapeutics
E Fokas, R Prevo, EM Hammond, TB Brunner… - Cancer treatment …, 2014 - Elsevier
The ataxia telangiectasia and Rad3-related (ATR) plays an important role in maintaining
genome integrity during DNA replication through the phosphorylation and activation of Chk1 …
genome integrity during DNA replication through the phosphorylation and activation of Chk1 …
Emerging strategies for cancer therapy by ATR inhibitors
K Yano, B Shiotani - Cancer Science, 2023 - Wiley Online Library
DNA replication stress (RS) causes genomic instability and vulnerability in cancer cells. To
counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling …
counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling …
Targeting ATR in cancer
E Lecona, O Fernandez-Capetillo - Nature Reviews Cancer, 2018 - nature.com
The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …
such as mustard gas present notable antitumoural properties. Consequently, early drug …
ATR inhibitor AZD6738
ABSTRACT AZD6738 is a potent and selective orally bio-available inhibitor of ataxia
telangiectasia and rad3 related (ATR), a key serine/threonine protein kinase involved in …
telangiectasia and rad3 related (ATR), a key serine/threonine protein kinase involved in …