Aqueous extract of Epimedium sagittatum mitigates pulmonary fibrosis in mice

R Wang, FY Hou, MN Zeng, BB Zhang… - Zhongguo Zhong yao …, 2023 - europepmc.org
This study aims to investigate the intervention effect of the aqueous extract of Epimedium
sagittatum Maxim on the mouse model of bleomycin (BLM)-induced pulmonary fibrosis, so …

Silica induced Expression of IL-1beta, IL-6, TNF-beta, TGF-alpha, in the Experimental Murine Lung Fibrosis

SY Ki, SW Park, MR Lee, EY Kim… - Tuberculosis and …, 1998 - synapse.koreamed.org
BACKGROUND: Silica-induced lung diseases is characterized by the accumulation of
inflammatory cells at early stage and fibrosis in pulmonary parenchyma and interstitium at …

Echistatin/BYL-719 impedes epithelial-mesenchymal transition in pulmonary fibrosis induced by silica through modulation of the Integrin β1/ILK/PI3K signaling …

H Li, P Wang, M Hu, S Xu, X Li, D Xu, K Feng… - International …, 2024 - Elsevier
Silicosis is a chronic fibroproliferative lung disease caused by long-term inhalation of
crystalline silica dust, characterized by the proliferation of fibroblasts and pulmonary …

Baicalin alleviates silica-induced lung inflammation and fibrosis by inhibiting the Th17 response in C57BL/6 mice

T Liu, W Dai, C Li, F Liu, Y Chen, D Weng… - Journal of natural …, 2015 - ACS Publications
Silicosis is an inflammatory and fibrotic lung disease caused by inhalation of silica. Th17
cells play a key role in causing silica-induced lung inflammation and fibrosis. Baicalin, a …

Syringic acid attenuates acute lung injury by modulating macrophage polarization in LPS-induced mice

WT Wang, YY Zhang, ZR Li, JM Li, HS Deng, YY Li… - Phytomedicine, 2024 - Elsevier
Background Acute lung injury (ALI) is a continuum of lung changes caused by multiple lung
injuries, characterized by a syndrome of uncontrolled systemic inflammation that often leads …

[HTML][HTML] Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and …

K Li, X Liu, R Hou, H Zhao, P Zhao, Y Tian… - … and Environmental Safety, 2023 - Elsevier
Abstract Background Baojin Chenfei formula (BCF), a Chinese herbal formula, has
significant effects on improving the clinical symptoms of patients with silicosis. However, its …

Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro

H Qin, HT Wen, KJ Gu, XD Hu, T Yang… - Drug Design …, 2019 - Taylor & Francis
Purpose Pulmonary fibrosis (PF) is a common clinical disease, which results in serious
respiratory impairment. Xin Jia Xuan Bai Cheng Qi Decoction (XJXBCQ) is a traditional …

Clearance of free silica in rat lungs by spraying with chinese herbal kombucha

N Fu, C Luo, J Wu, Y Zheng, Y Gan… - Evidence‐Based …, 2013 - Wiley Online Library
The effects of spraying with kombucha and Chinese herbal kombucha were compared with
treatments with tetrandrine in a rat silicosis model. Silica dust (50 mg) was injected into the …

Targeted Inhibition of ROCK Specifically in the Polarization Interstitial Macrophages Suppresses Pulmonary Fibrosis

Q Li, Y Cheng, Z Bi, X Ma, Y Wei, X Wei - 2021 - researchsquare.com
Background Pulmonary fibrosis (PF) is a kind of progressive interstitial lung disease with no
effective therapy. Rho/ROCK pathway has been confirmed to be activated in the process of …

[HTML][HTML] Combined intervention with N-acetylcysteine and desipramine alleviated silicosis development by regulating the Nrf2/HO-1 and ASMase/ceramide signaling …

M Tang, Z Yang, J Liu, X Zhang, L Guan, X Liu… - Ecotoxicology and …, 2022 - Elsevier
Silicosis is a systemic disease characterized by diffuse fibrosis of the lung tissue caused by
long-term inhalation of large amounts of free silica (SiO 2) dust. The pathogenesis of …