Background Silicosis represents a paramount occupational health hazard globally, with its
incidence, morbidity, and mortality on an upward trajectory, posing substantial clinical …

Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

Abstract Background Qing-Zao-Jiu-Fei Decoction (QZJFD) is a famous herbal formula
commonly prescribed for the treatment of lung-related diseases in the ancient and modern …

Background: Excessive accumulation of extracellular matrix is a key feature of pulmonary
fibrosis (PF), and myofibroblasts are the main producers of extracellular matrix. Fibroblasts …

Idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and
limited therapeutic strategies. In addition, the molecular mechanism by which pulmonary …

As a fatal occupational disease with limited therapeutic options, molecular mechanisms
underpinning silicosis are still undefined. Herein, single-cell RNA sequencing of the lung …

The role of ASMase/ceramide signaling pathway in the development of silicosis needs to be
verified by in vivo experiments. We investigated the role of the ASMase/ceramide signaling …

Occupational exposure to crystalline silica (CS) particles leads to silicosis, which is
characterized by chronic inflammation and abnormal tissue repair. Alveolar macrophages …

Pulmonary fibrosis (PF) is a lethal end stage of interstitial lung disease with increasing
prevalence. The disease burden of PF has seen a sharp surge in the past two decades …

Pulmonary fibrosis (PF) is a devastating interstitial lung disease resulting from indefinite
causes with very few limited, those too ineffective therapeutic options. Earlier evidence …