Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …

Animal models of acute ischemic stroke have been criticized for failing to translate to human
stroke. Nevertheless, animal models are necessary to improve our understanding of stroke …

Despite testing more than 1,026 therapeutic strategies in models of ischemic stroke and 114
therapies in human ischemic stroke, only one agent tissue plasminogen activator has …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

The high morbidity and mortality rate of ischemic stroke in humans has led to the
development of numerous animal models that replicate human stroke to further understand …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

Ischemic stroke is a devastating disease with a complex pathophysiology. Animal modeling
of ischemic stroke serves as an indispensable tool first to investigate mechanisms of …

Animal models of ischemic stroke are examples of an induced model that can present
challenges from the perspectives of protocol review and animal management. The review …

Preclinical ischemic stroke is at the crossroads in search of reliable and robust simulation
models as past experiences with their translation from the laboratory to the standard of …