天然产物是临床药物的主要来源, 也是新药研发过程中先导化合物结构设计和优化的灵感源泉.
但传统策略天然药源分子的发现却遭遇了瓶颈, 新颖天然产物的数量逐渐无法满足现代药物开发 …

天然产物是医药与农药的重要来源. 基因组测序和生物信息学分析技术的飞速发展,
揭示了大量功能未知的天然产物生物合成基因簇, 利用生物信息学工具, 从这些庞大的基因簇 …

Natural products and their derivatives from animals, plants and microorganisms are the main
sources of lead compounds in modern drug discovery and development. Canonical natural …

微生物可以产生结构多样, 活性显著的次级代谢产物, 为新药发现提供了丰富的化合物资源.
然而传统的研究模式已难以满足微生物源新药发现的需求, 迫切需要新的研究模式 …

Natural products have been an abundant source of leader compounds for new drugs, but
traditional isolation and analysis technologies to obtain novel natural products cannot satisfy …

Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a
wide variety of organisms in publicly accessible databases. Such data can be exploited to …

天然产物作为临床用药的重要组成部分和新药发现的重要来源, 已经成为医药领域不可或缺的
成员之一. 但是传统的天然产物筛选方法在一定程度上制约了新型天然产物的开发 …

Natural products are structurally highly diverse and exhibit a wide array of biological
activities. As a result, they serve as an important source of new drug leads. Traditionally …

Natural products continue to represent an excellent source for lead structures for drug
discovery. However, new concepts are required to increase the probability of finding new …

Novel natural products have always been the most important sources for discovery of new
drugs. Since the end of the 20th century, advances in genomics technology have contributed …