Rat mammary cancers generally resemble many features of human breast cancer. With the
recent developments in rat genetic engineering, the rat has become an excellent model …

Human breast cancer is a heterogeneous disease with numerous subtypes that have been
defined through immunohistological, histological, and gene expression patterns. The …

Transgenic breast cancer mouse models are critical tools for preclinical studies of human
breast cancer. Genetic editing of the murine mammary gland allows for modeling of …

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive
molecular and cellular research, the mortality rate remains high. Preclinical testing of new …

Mouse modeling of human breast cancer has developed tremendously over the past ten
years. Human breast cancer is characterized by enormous biological diversity and …

Rodent models have been, and continue to be, important in both defining the etiology of
breast cancer, and in generating new prevention and treatment strategies directed at this …

Rodent models for breast cancer have for many decades provided unparalleled insights into
cellular and molecular aspects of neoplastic transformation and tumorigenesis. Despite …

Genetically engineered mice are critical experimental models for the study of breast cancer
biology. Transgenic mice, employing strong mammary epithelial promoters to drive …

Literally thousands of specifically engineered mice have been created to study the
pathology, molecular biology, natural history and response to therapy in breast cancer. The …

Scores of genetically engineered mice have been generated in the quest to understand
mechanisms of breast cancer development and progression. More recently, there has been …