KLF13 Regulates the Activity of the GH-Induced JAK/STAT Signaling by Targeting Genes Involved in the Pathway
J Ávila-Mendoza, K Delgado-Rueda… - International Journal of …, 2023 - mdpi.com
The Krüppel-like factor 13 (KLF13) has emerged as an important transcription factor
involved in essential processes of the central nervous system (CNS). It predominantly …
involved in essential processes of the central nervous system (CNS). It predominantly …
KLF9 and JNK3 interact to suppress axon regeneration in the adult CNS
A Apara, J Galvao, Y Wang, M Blackmore… - Journal of …, 2017 - Soc Neuroscience
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …
Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice
Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and
reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem …
reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem …
Two sides of the same coin: the roles of KLF6 in physiology and pathophysiology
The Krüppel-like factors (KLFs) family of proteins control several key biological processes
that include proliferation, differentiation, metabolism, apoptosis and inflammation …
that include proliferation, differentiation, metabolism, apoptosis and inflammation …
Krüppel-like factors 9 and 13 block axon growth by transcriptional repression of key components of the cAMP signaling pathway
J Ávila-Mendoza, A Subramani… - Frontiers in molecular …, 2020 - frontiersin.org
Krüppel-like factors (KLFs) are zinc finger transcription factors implicated in diverse
biological processes, including differentiation of neural cells. The ability of mammalian …
biological processes, including differentiation of neural cells. The ability of mammalian …
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
AB Santos, A Carona, M Ettcheto, A Camins… - Acta Pharmacologica …, 2024 - nature.com
Epilepsy is a chronic and debilitating neurological disorder, known for the occurrence of
spontaneous and recurrent seizures. Despite the availability of antiseizure drugs, 30% of …
spontaneous and recurrent seizures. Despite the availability of antiseizure drugs, 30% of …
CKLF1 aggravates focal cerebral ischemia injury at early stage partly by modulating microglia/macrophage toward M1 polarization through CCR4
C Chen, SF Chu, QD Ai, Z Zhang, FF Guan… - Cellular and molecular …, 2019 - Springer
CKLF1 is a chemokine with increased expression in ischemic brain, and targeting CKLF1
has shown therapeutic effects in cerebral ischemia model. Microglia/macrophage …
has shown therapeutic effects in cerebral ischemia model. Microglia/macrophage …
Inhibition of KLF7-targeting microRNA 146b promotes sciatic nerve regeneration
WY Li, WT Zhang, YX Cheng, YC Liu, FG Zhai… - Neuroscience …, 2018 - Springer
A previous study has indicated that Krüppel-like factor 7 (KLF7), a transcription factor that
stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve …
stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve …
Endothelium‐targeted overexpression of Krüppel‐like factor 11 protects the blood‐brain barrier function after ischemic brain injury
Microvascular endothelial cell (EC) injury and the subsequent blood‐brain barrier (BBB)
breakdown are frequently seen in many neurological disorders, including stroke. We have …
breakdown are frequently seen in many neurological disorders, including stroke. We have …