KLF13 Regulates the Activity of the GH-Induced JAK/STAT Signaling by Targeting Genes Involved in the Pathway

J Ávila-Mendoza, K Delgado-Rueda… - International Journal of …, 2023 - mdpi.com
The Krüppel-like factor 13 (KLF13) has emerged as an important transcription factor
involved in essential processes of the central nervous system (CNS). It predominantly …

KLF9 and JNK3 interact to suppress axon regeneration in the adult CNS

A Apara, J Galvao, Y Wang, M Blackmore… - Journal of …, 2017 - Soc Neuroscience
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …

Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice

S Qin, M Liu, W Niu, CL Zhang - Proceedings of the …, 2011 - National Acad Sciences
Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and
reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem …

Two sides of the same coin: the roles of KLF6 in physiology and pathophysiology

SE Syafruddin, MA Mohtar, WF Wan Mohamad Nazarie… - Biomolecules, 2020 - mdpi.com
The Krüppel-like factors (KLFs) family of proteins control several key biological processes
that include proliferation, differentiation, metabolism, apoptosis and inflammation …

[引用][C] 人FKBP52 的基因克隆, 表达及活性研究

裴武红, 贺永怀, 陈兴, 李松, 沈倍奋 - 生物化学与生物物理进展, 2001

Krüppel-like factors 9 and 13 block axon growth by transcriptional repression of key components of the cAMP signaling pathway

J Ávila-Mendoza, A Subramani… - Frontiers in molecular …, 2020 - frontiersin.org
Krüppel-like factors (KLFs) are zinc finger transcription factors implicated in diverse
biological processes, including differentiation of neural cells. The ability of mammalian …

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

AB Santos, A Carona, M Ettcheto, A Camins… - Acta Pharmacologica …, 2024 - nature.com
Epilepsy is a chronic and debilitating neurological disorder, known for the occurrence of
spontaneous and recurrent seizures. Despite the availability of antiseizure drugs, 30% of …

CKLF1 aggravates focal cerebral ischemia injury at early stage partly by modulating microglia/macrophage toward M1 polarization through CCR4

C Chen, SF Chu, QD Ai, Z Zhang, FF Guan… - Cellular and molecular …, 2019 - Springer
CKLF1 is a chemokine with increased expression in ischemic brain, and targeting CKLF1
has shown therapeutic effects in cerebral ischemia model. Microglia/macrophage …

Inhibition of KLF7-targeting microRNA 146b promotes sciatic nerve regeneration

WY Li, WT Zhang, YX Cheng, YC Liu, FG Zhai… - Neuroscience …, 2018 - Springer
A previous study has indicated that Krüppel-like factor 7 (KLF7), a transcription factor that
stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve …

Endothelium‐targeted overexpression of Krüppel‐like factor 11 protects the blood‐brain barrier function after ischemic brain injury

X Zhang, X Tang, F Ma, Y Fan, P Sun, T Zhu… - Brain …, 2020 - Wiley Online Library
Microvascular endothelial cell (EC) injury and the subsequent blood‐brain barrier (BBB)
breakdown are frequently seen in many neurological disorders, including stroke. We have …