Noncoding RNA control of cellular senescence

K Abdelmohsen, M Gorospe - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
Senescent cells accumulate in normal tissues with advancing age and arise by long‐term
culture of primary cells. Senescence develops following exposure to a range of stress …

CIRCULATING MICRORNA PROFILE IN OKINAWAN CENTENARIANS

S Noureddine, S Ashiqueali, A Schneider… - Innovation in …, 2023 - ncbi.nlm.nih.gov
Centenarians are a successful example of aging and extended longevity, exhibiting
advanced regulation of biological mechanisms and homeostasis. Since human longevity is …

[HTML][HTML] Long non-coding RNA: insight into mechanisms of Alzheimer's disease

Z Lan, Y Chen, J Jin, Y Xu, X Zhu - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD), a heterogeneous neurodegenerative disorder, is the most
common cause of dementia accounting for an estimated 60-80% of cases. The …

[HTML][HTML] Recent advances on the role of long non-coding RNAs in Alzheimer's disease

K Doxtater, MK Tripathi, MM Khan - Neural Regeneration …, 2020 - journals.lww.com
Dementia is a progressive cognitive impairment that affects the activities of daily living.
Alzheimer's disease (AD) is the most common form of the dementia worldwide accounting …

Long non-coding RNAs in neurodegenerative diseases

S Yang, H Yang, Y Luo, X Deng, Y Zhou… - Neurochemistry …, 2021 - Elsevier
Neurodegenerative diseases are gradually becoming the main burden of society. The
morbidity and mortality caused by neurodegenerative diseases remain significant health …

[HTML][HTML] Role of lncRNAs in cellular aging

U Degirmenci, S Lei - Frontiers in endocrinology, 2016 - frontiersin.org
Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate
cellular processes including cellular senescence, telomere shortening, stem cell exhaustion …

Role of long non-coding RNAs in the pathophysiology of Alzheimer's disease and other dementias

LCR Teixeira, I Mamede, MR Luizon… - Molecular Biology …, 2024 - Springer
Dementia is the term used to describe a group of cognitive disorders characterized by a
decline in memory, thinking, and reasoning abilities that interfere with daily life activities …

[HTML][HTML] Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

L Qi, X Li, S Liu, D Jiao, D Hu, X Ju, S Zhao, S Si… - BMC neuroscience, 2022 - Springer
Background Dysregulation of long noncoding RNA (lncRNA) expression is related to aging
and age-associated neurodegenerative diseases, and the lncRNA expression profile in the …

[HTML][HTML] The function of lncRNAs in aging-related diseases and 3D genome

W Zhang, T Hu, X Song - Translational Medicine of Aging, 2019 - Elsevier
In the past decades, long noncoding RNAs (lncRNAs) have been indicated to play important
roles in almost every biological process. Aging is a gradual and irreversible biological …

Emerging roles of lnc RNA s in senescence

M Montes, AH Lund - The FEBS journal, 2016 - Wiley Online Library
Cellular senescence is a complex stress response that leads to an irreversible state of cell
growth arrest. Senescence may be induced by various stimuli such as telomere shortening …