MicroRNAs, aging, cellular senescence, and Alzheimer's disease

PH Reddy, J Williams, F Smith, JS Bhatti… - Progress in molecular …, 2017 - Elsevier
Aging is a normal process of living being. It has been reported that multiple cellular changes,
including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation …

Long non-coding RNAs in brain development, synaptic biology, and Alzheimer's disease

C Shi, L Zhang, C Qin - Brain research bulletin, 2017 - Elsevier
Long non-coding RNAs (lncRNAs), which are long transcripts without apparent protein-
coding roles, interfere with gene expression and signaling events at various stages …

[HTML][HTML] The role of tRNA-derived small RNAs in aging

SG Ha, SJV Lee - BMB reports, 2023 - ncbi.nlm.nih.gov
Aging is characterized by a gradual decline in biological functions, leading to the increased
probability of diseases and deaths in organisms. Previous studies have identified biological …

[HTML][HTML] From cellular senescence to age-associated diseases: the miRNA connection

E Schraml, J Grillari - Longevity & healthspan, 2012 - Springer
Cellular senescence has evolved from an in-vitro model system to study aging in vitro to a
multifaceted phenomenon of in-vivo importance as senescent cells in vivo have been …

Repetitive elements as a transcriptomic marker of aging: evidence in multiple datasets and models

TJ LaRocca, AN Cavalier, D Wahl - Aging Cell, 2020 - Wiley Online Library
Transcriptomic markers of aging can be useful for studying age‐related processes and
diseases. However, noncoding repetitive element (RE) transcripts, which may play an …

Senescence‐associated l nc RNA s: senescence‐associated long noncoding RNA s

K Abdelmohsen, A Panda, MJ Kang, J Xu… - Aging cell, 2013 - Wiley Online Library
Noncoding RNA s include small transcripts, such as micro RNA s and piwi‐interacting RNA
s, and a wide range of long noncoding RNA s (lnc RNA s). Although many lnc RNA s have …

Non-coding RNAs in Alzheimer's disease

L Tan, JT Yu, N Hu, L Tan - Molecular neurobiology, 2013 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common
dementia among the elderly. Accumulating research indicates that noncoding RNAs …

Biological Age in Healthy Elderly Predicts Dementia in the Absence of a Brain Marker

J Wu, A Yaqub, Y Ma, W Koudstaal, A Hofman… - 2020 - researchsquare.com
Application of biological age as a measure of an individuals health status offers new
perspectives into extension of both lifespan and healthspan. While algorithms predicting …

Identification of miRNAs as master regulators of aging signatures

VP Wagner - 2023 - publikationen.sulb.uni-saarland.de
Molecular mechanisms of organismal and cellular aging are only partially elucidated to this
date. Previous studies have focused on understanding the changes in the coding …

Research progress of aging-related microRNAs

Z Chen, C Li, H Huang, YL Shi… - Current Stem Cell …, 2024 - ingentaconnect.com
Senescence refers to the irreversible state in which cells enter cell cycle arrest due to
internal or external stimuli. The accumulation of senescent cells can lead to many age …