Activation of autoreactive CD4+ T cells is a crucial step in the development of T cell
mediated autoimmunity and crossreactivity between microbial and self antigens, a …

T cell receptor (TCR) recognition is intrinsically polyspecific. In the field of autoimmunity,
recognition of both self-and microbial peptides by a single TCR has led to the concept of …

A variety of mechanisms have been suggested as the means by which infections can initiate
and/or exacerbate autoimmune diseases. One mechanism is molecular mimicry, where a …

Objective To investigate the phenotype and the immunoregulatory function of CD8αα+
TCRαβ+ regulatory T cells in peripheral blood samples from mice. Methods The distribution …

Self-specific CD8 T cells, which are selected by high-affinity interactions with self-Ags,
develop into a lineage distinct from conventional CD8 T cells. We have previously shown …

Infection and vaccination can lead to activation of autoreactive T cells, including the
activation of cross-reactive T cells. However, detecting these cross-reactive T cells and …

The molecular-mimicry theory proposes that immune crossreactivity between microbial and
self-antigen is the initiating event in the activation of autoaggressive immune responses …

Self-reactive CD4 T cells are thought to have a central role in the pathogenesis of many
chronic inflammatory human diseases. Microbial peptides can activate self-reactive T cells …

T helper (Th) lymphocytes mediate critical effector and regulatory functions in infectious,
allergic, or autoimmune diseases. Th cells possess clonal receptors that recognize antigenic …

In humans, a substantial portion of T cells recognize lipids presented by the monomorphic
CD1 proteins. Recent studies have revealed the molecular basis of mycobacterial lipid …