摘要环氧‐二十碳三烯酸(Epoxyeicosatrienoic acids, EET) 是花生四烯酸的重要代谢产物. EET
在包括动脉粥样硬化, 高血压, 心脏纤维化, 糖尿病, 非酒精性脂肪肝以及肾脏疾病在内的诸多 …

Epoxides of free fatty acids (FFAs), especially epoxyeicosatrienoic acids (EETs), are lipid
mediators with beneficial effects in metabolic and cardiovascular (CV) health. FFA epoxides …

Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases
that have inflammation as a common underlying cause. sEH limits tissue levels of …

Despite the optimization of blood glucose control and the therapeutic management of risk
factors, obesity-and diabetes-induced cardiovascular diseases are still major health …

Background: Epoxyeicosatrienoic acids (EETs) have been shown to play a role in
cardiovascular protection by reducing ischemia reperfusion injury, producing anti …

The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Epoxyeicosatrienoic acids (EETs) reduce blood pressure by acting in the vasculature and
kidney, and interventions to increase circulating EETs improve insulin sensitivity and prevent …

Metabolic diseases are associated with an increased risk of developing cardiovascular
disease. The features comprising metabolic diseases include obesity, insulin resistance …

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome
P450 (CYP) epoxygenases have many biological functions. Importantly, CYP epoxygenase …