Background Similar to human breast cancer mammary tumors of the female dog are
commonly associated with a fatal outcome due to the development of distant metastases …

Mice have become the species of choice for modeling the complex interactions between
tumor cells and the host environment. Mouse genetics are easily manipulated, and a …

Breast cancer is a multifactorial disease that develops as a result of interactions among
genetic, environmental, and hormonal factors. Multiple genetic derangements are believed …

Introduction: Despite massive expenditures in research and development to cure breast
cancer, few agents that pass preclinical trials demonstrate efficacy in humans. Although this …

Triple-negative breast cancer (TNBC) has a more aggressive phenotype and higher
metastasis and recurrence rates than other breast cancer subtypes. TNBC currently lacks a …

Estrogen receptor-positive (ER+) tumors account for 70–80% of all breast cancer (BC) cases
and are characterized by estrogen dependency for their growth. Endocrine therapies using …

This is the second Special Issue addressing the diversity and use of animal models of breast
cancer. The previous issue (Breast Cancer Res Treat 39: 1-135, 1996), dealt with a variety of …

Modeling, an experimental approach to investigate complex biological systems, has
significantly contributed to our understanding of cancer. Although extensive cancer research …

Breast carcinoma is comprised of heterogeneous groups of cells with different metastatic
potential. To develop effective therapeutic strategies targeting metastatic disease, it is crucial …

Breast cancer is the most common cancer in women, and this prevalence has a major
impact on health worldwide. Localized breast cancer has an excellent prognosis, with a 5 …