Ethnopharmacological relevance Numerous studies have provided evidence supporting the
significant roles of icariin, in the prevention of multiple chronic diseases like diabetes, liver …

Background Idiopathic pulmonary fibrosis (IPF) is a debilitating interstitial lung disorder
characterized by its limited therapeutic interventions. Macrophages, particularly the …

Background and purpose The M2 polarization of macrophages substantially contributes to
the progression of pulmonary fibrosis (PF). Effective-compound combination (ECC), which is …

Pulmonary fibrosis is a manifestation of the progression of interstitial pulmonary disease.
Icariin (ICA) has been found to exhibit protective effects on multiple chronic diseases like …

OBJECTIVE To study the therapeutic effect and the underlying mechanism of asiaticoside on
bleomycin-induced rat interstitial pulmonary fibrosis (IPF). METHODS Male Sprague-Dawley …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia
with limited therapeutic options. Eucalyptol, a terpenoid oxide isolated from eucalyptus …

Peimine, a bioactive substance isolated from Chinese medicine Fritillaria, can potentially
suppress pulmonary fibrosis (PF); however, its therapeutic mechanism remains unclear …

Idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and
limited therapeutic strategies. In addition, the molecular mechanism by which pulmonary …

Objectives Pulmonary fibrosis (PF) is a chronic and refractory interstitial lung disease with
limited therapeutic options. 4-octyl itaconate (4-OI), a cell-permeable derivative of itaconate …

Pulmonary fibrosis is a progressive, irreversible, and fatal fibrotic lung disease with a high
mortality and morbidity, and commonly nonresponsive to conventional therapy. Inula …