Seeking new anti-cancer agents from autophagy-regulating natural products

F Hua, S Shang, ZW Hu - Journal of Asian natural products …, 2017 - Taylor & Francis
Natural products are an important original source of many widely used drugs, including anti-
cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural …

[HTML][HTML] Targeting autophagy with natural products as a potential therapeutic approach for cancer

MAA Al-Bari, Y Ito, S Ahmed, N Radwan… - International journal of …, 2021 - mdpi.com
Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-
digestion caused by lysosomes on demand, which is upregulated as a survival strategy …

Research progress on the anticancer molecular mechanism of targets regulating cell autophagy

T Zhang, J Yu, S Cheng, Y Zhang, C Zhou, J Qin… - Pharmacology, 2023 - karger.com
Background: Autophagy is a lysosome-mediated catabolic process that maintains cell
homeostasis and survival. It occurs not only in normal cells such as cardiac muscle cells …

Natural product regulates autophagy in cancer

Y Xiaokaiti, X Li - Autophagy: Biology and Diseases: Clinical Science, 2020 - Springer
Anti-cancer effect of natural products has been widely known. As a sort of multi-target anti-
cancer agents, natural compound's regulation on autophagy in cancer cells has been …

Natural autophagy regulators in cancer therapy: a review

Q Ding, J Bao, W Zhao, Y Hu, J Lu, X Chen - Phytochemistry Reviews, 2015 - Springer
Autophagy is a complicated self-eating response of cells to external or internal stimuli. This
process involves cellular degradation through the lysosomes of dysfunctional or …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

[HTML][HTML] New visions on natural products and cancer therapy: autophagy and related regulatory pathways

A Martelli, M Omrani, M Zarghooni, V Citi, S Brogi… - Cancers, 2022 - mdpi.com
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

Autophagy and its potent modulators from phytochemicals in cancer treatment

CY Sun, QY Zhang, GJ Zheng, B Feng - Cancer chemotherapy and …, 2019 - Springer
Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …

[HTML][HTML] Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Discovery of small molecules that target autophagy for cancer treatment

L Wu, B Yan - Current medicinal chemistry, 2011 - ingentaconnect.com
Autophagy is a self-renewal process in cells by recycling redundant materials through
lysosomal machinery. The basal level of autophagy in eukaryotic cells plays a …