In this paper, based on Hill dynamics and michaelis r menten equation, we built a theoretical
model tostudy the physical mechanism of VPRBP protein and Abl kinase inducing and …

As one of the key proteins, wild-type p53 can inhibit the tumor development and regulate the
cell fate. Thus, the study on p53 and its related kinetics has important physiological …

The p53 network is the most important pathway involved in preventing the initiation of
cancer. More than half of all human cancers contain mutations in the p53 gene and in almost …

Prostate cancer (PCa) is one of the major causes of cancer death among males worldwide.
Our previous studies indicated that the proliferation of prostate cancer cells was reduced …

Eukaryotic cells are exposed continuously to the genotoxic stresses caused by various
sources, such as ionizing radiation (IR) that generates DNA double-strand breaks (DSBs). In …

p53 kinetics plays a key role in regulating cell fate. Based on the p53 gene regulatory
network composed by the core regulatory factors ATM, Mdm2, Wip1, and PIDD, the effect of …

The activation and stabilization of tumor suppressor p53 are very important in preventing
cells from becoming cancerous. Hence, many experimental works have been carried out to …

The incidence of prostate cancer in the world is increasing every year. Death caused by
prostate cancer is increased by 13% in men between 1980 and 2005. It is the second …

Base on new experimental results, we give a dynamical model to study the dynamical
mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated …

Radiotherapy for prostate cancer has been gradually carried out in recent years; however,
acquired radioresistance often occurred in some patients after radiotherapy. HBP1 (HMG …