随着精准医学概念的提出, 肿瘤作为一类高度异质性的疾病, 其个体化治疗已成为精准医学的
一个关键领域也受到更多关注. 近期提出的类器官模型为肿瘤的基础研究和个体化治疗带来了新 …

类器官技术的发展为更接近机体细胞组成和病理生理特征的癌症模型开辟了新途径.
患者来源的肿瘤类器官在多次传代后仍能维持原有肿瘤的组织病理学及遗传表型特征 …

The tumor microenvironment (TME) is critical for tumor growth and metastasis. The TME
contains cancer-associated cells, tumor matrix, and tumor secretory factors. The fabrication …

The generation of three-dimensional (3D) cancer models is a novel and fascinating
development in the study of personalized medicine and tumor-specific drug delivery. In …

Despite the advancements in biomarker-based personalized cancer therapy, the
inadequacy of molecular and genetic profiling in identifying effective drug combinations was …

Cell models are indispensable for the research and development of cancer therapies.
Cancer medications have evolved with the establishment of various cell models. Patient …

As organ-specific three-dimensional cell clusters derived from cancer tissue or cancer-
specific stem cells, cancer-derived organoids are organized in the same manner of the cell …

As a reductionist approach, patient‐derived in vitro tumor models are inherently still too
simplistic for personalized drug testing as they do not capture many characteristics of the …

Recently, an original article titled “A patient-derived glioblastoma organoid model and
biobank recapitulates inter-and intra-tumoral heterogeneity” was published in Cell (1), a …

Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …