Bleomycin (BLM), a frequently employed chemotherapeutic agent, exhibits restricted clinical
utility owing to its pulmonary toxicity. Meanwhile, baicalin (BA)—an active ingredient …

Baicalin is an important flavonoid compound THAT is isolated from the Scutellaria
baicalensis Georgi Chinese herb and plays a critical role in anti‑oxidative, anti‑inflammatory …

Background Baicalin has been reported to have anti-fibrosis effect; however, its mechanism
still remains to be elucidated. Adenosine A2a receptor (A2aR) is a novel inflammation …

Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to
respiratory failure and death. Vincamine is an indole alkaloid obtained from the leaves of …

Aloperine is a quinolizidine alkaloid extracted from Sophora alopecuroides. It has been
proven to alleviate oxidative stress and effectively promote tumor cell apoptosis in mice …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by epithelial
cell damage, fibroblast activation, and collagen deposition. IPF has high mortality and …

Currently, there is no satisfactory treatment for pulmonary fibrosis, and effective agents
urgently need to be developed. The aim of the present study was to investigate the effects of …

Idiopathic pulmonary fibrosis is a progressive, degenerative and almost irreversible disease.
There is hardly an effective cure for lung damage due to pulmonary fibrosis. The purpose of …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal and progressive fibrotic lung
disease lacking a validated and effective therapy. Aberrant activation of the Wnt/β-catenin …

Numerous studies demonstrated that bleomycin (BLM) caused acute lung injury (ALI). This
study explored the role of mitochondrial reactive oxygen species (ROS) on BLM-induced ALI …