卵母细胞及胚胎发育的微环境中, 由氧气参与新陈代谢所产生的一些活性氧物质如得不到及时
清除, 会诱导氧化应激的现象. 有研究显示, 氧化应激是影响卵母细胞质量和胚胎发育潜能的主要 …

氧化应激的发生源于反应性氧化物与生物抗氧化剂之间的平衡破坏, 造成活性氧浓度升高,
导致细胞氧化损伤. 人类许多不同生殖状态下都存在氧化应激状态, 尤其是辅助生殖技术(ART) …

氧化损伤是由活性氧(reactive oxygen species, ROS) 产生和清除失衡所致, 主要包括DNA,
蛋白和脂质的氧化损伤. 过量ROS 损伤可以导致核DNA 和线粒体DNA 突变或缺失 …

卵泡液作为一个生物学“窗口” 反映了卵母细胞代谢及成熟变化过程, 同时也是卵母细胞成熟度,
受精率, 卵裂率及妊娠率各参数的非侵入性预测物. 卵泡液环境中存在活性氧(ROS) …

Significance: To improve the outcomes of in vitro culture of human oocytes and embryos, the
dynamic balance and roles of reactive oxygen species (ROS) in folliculogenesis and embryo …

Oxidative stress is involved in the aetiology of defective embryo development. Reactive
oxygen species (ROS) may originate from embryo metabolism and/or embryo surroundings …

In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

One principal purpose of assisted reproductive technology (ART) is to produce viable and
good quality embryos. However, a variety of environmental factors may induce epigenetic …

Oxidative stress characterized by elevated reactive oxygen species is a well-known cause of
developmental arrest and cellular fragmentation in the development of in vitro-produced …