The high morbidity and mortality rate of ischemic stroke in humans has led to the
development of numerous animal models that replicate human stroke to further understand …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …

On average, every 4 min an individual dies from a stroke, accounting for one out of every 18
deaths in the United States. Approximately 795,000 Americans have a new or recurrent …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

Stroke is one of the major healthcare challenges prevailing across the globe due to its
significant rate of mortality and morbidity. Stroke is multifactorial in nature and involves …

Publisher Summary Animal stroke models have played a unique role in understanding
normal and ischemic brain metabolism and function. Sophisticated methods for the …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Animal models of ischemic stroke are examples of an induced model that can present
challenges from the perspectives of protocol review and animal management. The review …

Despite testing more than 1,026 therapeutic strategies in models of ischemic stroke and 114
therapies in human ischemic stroke, only one agent tissue plasminogen activator has …