Tau-targeted therapy in Alzheimer's disease: History and current state

A Jurcau, VS Nunkoo - Frontiers in Clinical Drug Research, 2021 - books.google.com
The two main histopathological hallmarks still required for the diagnosis of Alzheimer's
disease are the presence of amyloid plaques and intraneuronal neurofibrillary tangles …

[PDF][PDF] Tau-targeting therapy in Alzheimer's disease: Critical advances and future opportunities

Y Guo, S Li, LH Zeng, J Tan - Ageing Neurodegener. Dis, 2022 - f.oaes.cc
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by two
pathological hallmark lesions: extracellular plaques composed of β-amyloid (Aβ) peptide …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

An overview on the clinical development of tau-based therapeutics

M Medina - International journal of molecular sciences, 2018 - mdpi.com
Tauopathies such as Alzheimer's disease (AD), frontotemporal lobar degeneration, or
progressive supranuclear palsy constitute a group of brain disorders defined by …

Tau-based therapies for Alzheimer's disease: Promising novel neuroprotective approaches

CL Sayas - … in Autism, Schizophrenia and Alzheimer's Disease, 2020 - Elsevier
Tau neurofibrillary tangles and amyloid-β plaques are the two main hallmarks of Alzheimer's
disease (AD). In AD, tau undergoes conformational changes and subsequent seeding …

Tau biology and tau-directed therapies for Alzheimer's disease

L Bakota, R Brandt - Drugs, 2016 - Springer
Alzheimer's disease (AD) is characterised by a progressive loss of cognitive functions.
Histopathologically, AD is defined by the presence of extracellular amyloid plaques …

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

KR Brunden, JQ Trojanowski, VMY Lee - Nature reviews Drug …, 2009 - nature.com
Neuronal inclusions comprised of the microtubule-associated protein tau are found in
numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's …

Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy

J Ye, H Wan, S Chen, GP Liu - Neural Regeneration Research, 2024 - journals.lww.com
Alzheimer's disease is the most prevalent neurodegenerative disease affecting older adults.
Primary features of Alzheimer's disease include extracellular aggregation of amyloid-β …

Targeting tau protein in Alzheimer's disease

CX Gong, I Grundke-Iqbal, K Iqbal - Drugs & aging, 2010 - Springer
Alzheimer's disease (AD) is characterized histopathologically by numerous neurons with
neurofibrillary tangles and neuritic (senile) amyloid-β (Aβ) plaques, and clinically by …

Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …