Hyperoside attenuates bleomycin-induced pulmonary fibrosis development in mice

J Huang, X Tong, L Zhang, Y Zhang, L Wang… - Frontiers in …, 2020 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal, and chronic lung disease. There
are no effective drug therapies for IPF. Hyperoside, a flavonoid glycoside, has been proven …

Sodium houttuyfonate inhibits bleomycin induced pulmonary fibrosis in mice

Y Shen, M Cheng, X Liu, D Zhu, J Gao - Frontiers in Pharmacology, 2021 - frontiersin.org
Pulmonary fibrosis (PF) could severely disrupt the normal lung architecture and function with
fatal consequences. Currently, there is no effective treatment for PF or idiopathic pulmonary …

Gentiopicroside ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibiting inflammatory and fibrotic process

C Chen, Y Wang, Y Wang, M Cheng, J Yin… - Biochemical and …, 2018 - Elsevier
Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various
causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients …

Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation

R Guan, X Wang, X Zhao, N Song, J Zhu, J Wang… - Scientific reports, 2016 - nature.com
Aberrant activation of TGF-β1 is frequently encountered and promotes epithelial-
mesenchymal transition (EMT) and fibroblast activation in pulmonary fibrosis. The present …

Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo

SY Ma, WS Park, DS Lee, G Choi, MJ Yim… - European journal of …, 2017 - Elsevier
Pulmonary fibrosis, a potentially fatal disease, results from acute and chronic interstitial lung
diseases. Fucoxanthin (Fx), a carotenoid found in brown seaweed, shows a wide range of …

Emodin alleviates bleomycin-induced pulmonary fibrosis in rats

R Guan, X Zhao, X Wang, N Song, Y Guo, X Yan… - Toxicology Letters, 2016 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with few treatment options and
poor prognosis. Emodin, extracted from Chinese rhubarb, was found to be able to alleviate …

Osthole alleviates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2/angiotensin-(1–7) axis and decreasing inflammation …

Y Hao, Y Liu - Biological and Pharmaceutical Bulletin, 2016 - jstage.jst.go.jp
Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in
lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary …

Azithromycin attenuates bleomycin-induced pulmonary fibrosis partly by inhibiting the expression of LOX and LOXL-2

X Tong, S Zhang, D Wang, L Zhang, J Huang… - Frontiers in …, 2021 - frontiersin.org
Pulmonary fibrosis (PF) is a chronic and progressive process of tissue repair. Azithromycin
(AZM) may be beneficial for the treatment of PF because AZM has anti-inflammatory and …

Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment

AC Rosa, A Pini, L Lucarini, C Lanzi, E Veglia… - … of Pharmacology and …, 2014 - ASPET
Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation
and accumulation of extracellular matrix components, is a major therapeutic challenge for …

[HTML][HTML] Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB …

Z Zhou, AD Kandhare, AA Kandhare… - EXCLI …, 2019 - ncbi.nlm.nih.gov
Bleomycin (BLM) is a chemotherapeutic agent which is associated with Idiopathic
pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has …