DNA 损伤是影响配子发生和胚胎发育的关键因素之一. 卵母细胞容易被各种内外源因素(如活性
氧, 辐射, 化疗药物等) 诱发DNA 损伤. 目前研究发现, 对于各类DNA 损伤 …

DNA damage is one of the key factors affecting gametogenesis and embryo development.
Oocytes are susceptible to DNA damage induced by various endogenous and exogenous …

着床前受精卵对其内外环境十分敏感, 体内或是体外发育过程中的各种遗传毒性压力(genotoxic
stress), 以及受损的精子或卵子均可引起受精卵的DNA 损伤. 尽管精子成熟过程中其DNA …

DNA damage in cells can occur physiologically or may be induced by exogenous factors.
Genotoxic damage may cause cancer, ageing, serious developmental diseases and …

迄今为止, 人们普遍认为成熟精子DNA 损伤后不能自行修复. 由于DNA 损伤精子仍具有受精
能力和发育潜力, 其修复可能在受精后阶段, 但其具体修复机制还不清楚. 目前, 对于DNA …

DNA damage is one of the most common insults that challenge all cells. To cope, an
elaborate molecular and cellular response has evolved to sense, respond to and correct the …

Mammalian cells have developed complex mechanisms to identify DNA damage and
activate the required response to maintain genome integrity. Those mechanisms include …

Female fertility and offspring health are critically dependent on an adequate supply of high-
quality oocytes, the majority of which are maintained in the ovaries in a unique state of …

DNA damage is a critical threat that poses significant challenges to all cells. To address this
issue, cells have evolved a sophisticated molecular and cellular process known as the DNA …

Female fertility and offspring health are critically dependent on the maintenance of an
adequate supply of high-quality oocytes. Like somatic cells, oocytes are subject to a variety …