揭示阿尔茨海默病中的DNA 甲基化: 基于阵列的人脑研究综述

VC Alves, E Carro, J Figueiro-Silva - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by
the exploration of epigenetic mechanisms, particularly DNA methylation. This review …

[HTML][HTML] Unveiling DNA methylation in Alzheimer's disease: a review of array-based human brain studies

VC Alves, E Carro, J Figueiro-Silva - Neural Regeneration …, 2024 - journals.lww.com
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by
the exploration of epigenetic mechanisms, particularly DNA methylation. This review …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

[HTML][HTML] Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

AR Smith, RG Smith, E Pishva, E Hannon… - Clinical …, 2019 - Springer
Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …

[HTML][HTML] DNA methylation, a hand behind neurodegenerative diseases

H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …

A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease

J Zhao, Y Zhu, J Yang, L Li, H Wu, PL De Jager… - Alzheimer's & …, 2017 - Elsevier
Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …

Targeted bisulfite sequencing analysis of Alzheimer's disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal …

G Wheildon, AR Smith, D Soanes… - Alzheimer's & …, 2023 - Wiley Online Library
Background Recent epigenome‐wide association studies (EWAS) identified several loci in
specific genes showing robust and reproducible alterations in DNA methylation in …

[HTML][HTML] DNA methylation in neurodegenerative disorders

Z Xu, X Li - Current Geriatrics Reports, 2012 - Springer
Epigenetic mechanisms are essential in a host of biological processes and many different
human diseases. Epigenetic modifications include DNA methylation, histone modification …

Elevated DNA methylation across a 48‐kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

RG Smith, E Hannon, PL De Jager… - Alzheimer's & …, 2018 - Wiley Online Library
Introduction Alzheimer's disease is a neurodegenerative disorder that is hypothesized to
involve epigenetic dysregulation of gene expression in the brain. Methods We performed an …