揭示阿尔茨海默病中的DNA 甲基化: 基于阵列的人脑研究综述
VC Alves, E Carro, J Figueiro-Silva - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by
the exploration of epigenetic mechanisms, particularly DNA methylation. This review …
the exploration of epigenetic mechanisms, particularly DNA methylation. This review …
[HTML][HTML] Unveiling DNA methylation in Alzheimer's disease: a review of array-based human brain studies
VC Alves, E Carro, J Figueiro-Silva - Neural Regeneration …, 2024 - journals.lww.com
The intricacies of Alzheimer's disease pathogenesis are being increasingly illuminated by
the exploration of epigenetic mechanisms, particularly DNA methylation. This review …
the exploration of epigenetic mechanisms, particularly DNA methylation. This review …
Epigenetics in Alzheimer's disease: perspective of DNA methylation
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …
understood, but over the past years, the involvement of epigenetic mechanisms in the …
[HTML][HTML] Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease
Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …
[HTML][HTML] DNA methylation, a hand behind neurodegenerative diseases
H Lu, X Liu, Y Deng, H Qing - Frontiers in aging neuroscience, 2013 - frontiersin.org
Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …
DNA methylation in the pathology of Alzheimer's disease: from gene to cognition
CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …
deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although …
A genome-wide profiling of brain DNA hydroxymethylation in Alzheimer's disease
Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …
Targeted bisulfite sequencing analysis of Alzheimer's disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal …
G Wheildon, AR Smith, D Soanes… - Alzheimer's & …, 2023 - Wiley Online Library
Background Recent epigenome‐wide association studies (EWAS) identified several loci in
specific genes showing robust and reproducible alterations in DNA methylation in …
specific genes showing robust and reproducible alterations in DNA methylation in …
[HTML][HTML] DNA methylation in neurodegenerative disorders
Z Xu, X Li - Current Geriatrics Reports, 2012 - Springer
Epigenetic mechanisms are essential in a host of biological processes and many different
human diseases. Epigenetic modifications include DNA methylation, histone modification …
human diseases. Epigenetic modifications include DNA methylation, histone modification …
Elevated DNA methylation across a 48‐kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology
Introduction Alzheimer's disease is a neurodegenerative disorder that is hypothesized to
involve epigenetic dysregulation of gene expression in the brain. Methods We performed an …
involve epigenetic dysregulation of gene expression in the brain. Methods We performed an …