Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus: 重新评价金属硫蛋白: 对糖尿病患者的临床意义

Y Park, J Zhang, L Cai - Journal of Diabetes, 2018 - Wiley Online Library
摘要活性氧以及活性氮(Reactive oxygen species, ROS; Reactive nitrogen species, RNS)
是细胞中间营养物质生理代谢过程中的副产品. 虽然生理防御机制可以迅速将这类物资转化成水 …

Diabetes and metallothionein

X Li, LU Cai, W Feng - Mini Reviews in Medicinal Chemistry, 2007 - ingentaconnect.com
Diabetes is a widespread disease, and its development and toxic effects on various organs
have been attributed to increased oxidative stress. Metallothionein (MT) is a group of …

Emerging roles of metallothioneins in beta cell pathophysiology: beyond and above metal homeostasis and antioxidant response

M Bensellam, DR Laybutt, JC Jonas - Biology, 2021 - mdpi.com
Simple Summary Defective insulin secretion by pancreatic beta cells is key for the
development of type 2 diabetes but the precise mechanisms involved are poorly understood …

Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease

W Maret, A Krężel - Molecular medicine, 2007 - Springer
Zinc is involved in virtually all aspects of cellular and molecular biology as a catalytic,
structural, and regulatory cofactor in over 1000 proteins. Zinc binding to proteins requires an …

Diabetes, metallothionein, and zinc interactions: a review

MS Islam, DT Loots - Biofactors, 2007 - Wiley Online Library
Epidemiological evidence, associating diabetes with zinc (Zn) deficiencies, has resulted in
numerous research studies describing the effects of Zn and associated metallothionein (MT) …

Tissue metallothionein concentrations in mice and humans with hyperglycemia

MD Chen, YM Song - Biological trace element research, 2009 - Springer
Besides participating in tissue zinc homeostasis and protecting against heavy metal
toxicities, metallothionein (MT) is known as an antioxidant. Increased MT activity can …

A role for metallothionein in the pathogenesis of diabetes and its cardiovascular complications

W Maret - Molecular genetics and metabolism, 2008 - Elsevier
It has been suspected for a long time that zinc has a role in various aspects of diabetes, but
specific molecular targets of zinc remained largely elusive. Recent discoveries of …

金属硫蛋白的生物学效应

李淑敏, 胡大一 - 国外医学: 生理病理科学与临床分册, 1996 - cqvip.com
金属硫蛋白的生物学效应-[维普官方网站]-www.cqvip.com-维普网  我的维普 购物车 充值 客服
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Metallothionein as an adaptive protein prevents diabetes and its toxicity

L Cai - Nonlinearity in biology, toxicology, medicine, 2004 - journals.sagepub.com
Metallothioneins (MTs) are a group of intracellular metal-binding and cysteine-enriched
proteins and are highly inducible in many tissues in response to various types of stress …

Zinc sulphate induces metallothionein in pancreatic islets of mice and protects against diabetes induced by multiple low doses of streptozotocin

P Ohly, C Dohle, J Abel, J Seissler, H Gleichmann - Diabetologia, 2000 - Springer
Aims/hypothesis. Diabetes is induced by multiple low doses of streptozotocin (MLD-STZ) in
male mice of susceptible strains. In this model beta-cell injury and T-cell-mediated …