Behavioral control by striatal adenosine A2A‐dopamine D2 receptor heteromers
J Taura, M Valle‐León, K Sahlholm… - Genes, Brain and …, 2018 - Wiley Online Library
G protein‐coupled receptors (GPCR) exhibit the ability to form receptor complexes that
include molecularly different GPCR (ie, GPCR heteromers), which endow them with singular …
include molecularly different GPCR (ie, GPCR heteromers), which endow them with singular …
The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 …
JF Chen, R Moratalla, F Impagnatiello… - Proceedings of the …, 2001 - National Acad Sciences
The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …
Adenosine receptor–dopamine receptor interactions in the basal ganglia and their relevance for brain function
The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …
Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A receptor antagonist
S Aoyama, H Kase, E Borrelli - Journal of Neuroscience, 2000 - Soc Neuroscience
In Parkinson's disease a degeneration of dopaminergic neurons of the nigrostriatal pathway
is observed. Loss of dopaminergic regulation of striatal neuron activity results in altered …
is observed. Loss of dopaminergic regulation of striatal neuron activity results in altered …
Adenosine A2A receptors modulate the dopamine D2 receptor‐mediated inhibition of synaptic transmission in the mouse prefrontal cortex
JI Real, AP Simoes, RA Cunha… - European Journal of …, 2018 - Wiley Online Library
Prefrontal cortex (PFC) circuits are modulated by dopamine acting on D1‐and D2‐like
receptors, which are pharmacologically exploited to manage neuropsychiatric conditions …
receptors, which are pharmacologically exploited to manage neuropsychiatric conditions …
Evidence for the heterotetrameric structure of the adenosine A2A–dopamine D2 receptor complex
V Casadó-Anguera, J Bonaventura… - Biochemical Society …, 2016 - portlandpress.com
Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel
targets for drug development. Accumulating evidence indicates that GPCRs can form …
targets for drug development. Accumulating evidence indicates that GPCRs can form …
Functional Uncoupling of Adenosine A2A Receptors and Reduced Response to Caffeine in Mice Lacking Dopamine D2Receptors
NR Zahniser, JK Simosky, RD Mayfield… - Journal of …, 2000 - Soc Neuroscience
Dopamine D2 receptors (Rs) and adenosine A2ARs are coexpressed on striatopallidal
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …
An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors
Adenosine A2A-dopamine D2 receptor interactions play a very important role in striatal
function. A2A-D2 receptor interactions provide an example of the capabilities of information …
function. A2A-D2 receptor interactions provide an example of the capabilities of information …
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission
A Tozzi, A Tscherter, V Belcastro, M Tantucci… - …, 2007 - Elsevier
Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …
Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat …
I Strömberg, P Popoli, CE Müller… - European Journal of …, 2000 - Wiley Online Library
It has been shown that striatal adenosine A2A receptors can antagonistically interact with
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …