敲低NLRX1 可上调线粒体融合蛋白并减轻缺氧心肌细胞凋亡
王林一， 贺广祥， 梁郡， 史睿， 李慢， 裴建明， 杨彦玲… - 心脏杂志, 2023 - heartj.cn
敲低NLRX1 可上调线粒体融合蛋白并减轻缺氧心肌细胞凋亡NLRX1 knockdown up-regulates
expression level of mi Page 1 • 基础研究 • 敲低NLRX1 可上调线粒体融合蛋白并减轻缺氧心肌 …
expression level of mi Page 1 • 基础研究 • 敲低NLRX1 可上调线粒体融合蛋白并减轻缺氧心肌 …
NLRP3 介导的细胞焦亡在心肌细胞缺氧/复氧损伤中的作用
岳荣川， 卢圣忠， 罗瑜， 曾静， 梁豪， 王小波， 秦丹… - 中华心血管病 …, 2019 - cqvip.com
目的探讨核苷酸结合寡聚化结构域样受体蛋白3 (NLRP3) 介导的细胞焦亡在心肌细胞缺氧/复氧
损伤中的作用. 方法为明确缺氧/复氧是否会引起细胞焦亡, 采用抓阄法将H9c2 …
损伤中的作用. 方法为明确缺氧/复氧是否会引起细胞焦亡, 采用抓阄法将H9c2 …
[HTML][HTML] NLRX1 deletion increases ischemia-reperfusion damage and activates glucose metabolism in mouse heart
H Zhang, Y Xiao, R Nederlof, D Bakker… - Frontiers in …, 2020 - frontiersin.org
Background NOD-like receptors (NLR) are intracellular sensors of the innate immune
system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia …
system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia …
The innate immune receptor NLRX1 protects against cardiac ischemia/reperfusion injury through RISK signaling, mPTP regulation and inhibition of mitochondrial …
Y Xiao, C Rudolphi, E Nollet, D Bakker… - Journal of Molecular and …, 2022 - Elsevier
Methods NLRX1 expression levels were determined in post-IR mouse and pig hearts, and in
heart failure (HF) human hearts. Isolated C57Bl/6 J (WT) and NLRX1 knock-out (KO) mouse …
heart failure (HF) human hearts. Isolated C57Bl/6 J (WT) and NLRX1 knock-out (KO) mouse …
NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation
H Li, S Zhang, F Li, L Qin - Molecular Immunology, 2016 - Elsevier
Increasing evidence suggests that inflammation and apoptosis are involved in the
development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization …
development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization …
人心肌细胞中NLRP3 融合蛋白表达的鉴定
齐斌， 任威， 李春江， 张锐 - 广西医学, 2014 - cqvip.com
目的: 构建人NLRP3 真核表达载体并证实NLRP3 融合蛋白在人心肌细胞中表达.
方法以人胎脑cDNA 文库为模版, PCR 扩增NLRP3 全长编码基因, 亚克隆至pCDNA3. 1-myc …
方法以人胎脑cDNA 文库为模版, PCR 扩增NLRP3 全长编码基因, 亚克隆至pCDNA3. 1-myc …
[HTML][HTML] NLRX1 的生理功能及在呼吸系统疾病中的研究进展
肖江， 朱成杰， 商艳， 白冲 - 第二军医大学学报, 2021 - html.rhhz.net
核苷酸结合寡聚化结构域(NOD) 和富含亮氨酸重复序列的家族蛋白X1 (NLRX1) 是NOD
样受体(NLR) 家族的一员, 是免疫系统的重要调节因子. 研究表明, NLRX1 能够调控NF-κB …
样受体(NLR) 家族的一员, 是免疫系统的重要调节因子. 研究表明, NLRX1 能够调控NF-κB …
TXNIP 介导的NLRP3 炎症小体激活在心肌微血管内皮细胞缺氧/复氧损伤中的作用
许倡涛， 刘毅， 朱迪， 辛超， 杜志超， 穆楠， 陶凌 - 心脏杂志, 2015 - cqvip.com
目的研究硫氧还蛋白结合蛋白(TXNIP) 介导的NLRP3 炎症小体激活在心肌微血管内皮细胞(
CMECs) 缺氧/复氧(H/R) 损伤中的作用. 方法分离培养C57BL/6J 小鼠CMECs, 随机分为对照组 …
CMECs) 缺氧/复氧(H/R) 损伤中的作用. 方法分离培养C57BL/6J 小鼠CMECs, 随机分为对照组 …
NLRP3 in myocardial ischaemia–reperfusion injury: inflammasome-dependent or-independent role in different cell types
M Takahashi - Cardiovascular research, 2013 - academic.oup.com
An accumulating body of evidence has indicated that inflammation in the absence of
pathogens, which is referred to as sterile inflammation, is mediated through an …
pathogens, which is referred to as sterile inflammation, is mediated through an …
[HTML][HTML] NLRP3 deficiency reduces macrophage interleukin-10 production and enhances the susceptibility to doxorubicin-induced cardiotoxicity
M Kobayashi, F Usui, T Karasawa, A Kawashima… - Scientific reports, 2016 - nature.com
NLRP3 inflammasomes recognize non-microbial danger signals and induce release of
proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular …
proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular …