Objective To investigate the mechanism of CyGB and HMGB1 expression after Xuesaitong
intervention in rats with cardiac arrest by establishing rat models of cardiac …

ObjectiveTo investigate the influence of Tanshinone Ⅱ A on the expression of HMGB1 in
rats with cerebral ischemia-reperfusion (I/R) injury and its neural function protection …

Excessive inflammatory response produced after cardiac arrest and cardiopulmonary
resuscitation (CA/CPR) is one of major causes of cerebral injury. High mobility group box 1 …

Cardiac arrest (CA), if untreated for more than 5 min, can induce severe brain damage, the
underlying mechanism of which is still unclear. Previous studies have indicated that high …

Abstract High-mobility Group Box-1 (HMGB1) is a central late proinflammatory cytokine that
triggers the inflammatory response during sepsis. However, whether HMGB1 is involved in …

Abstract JNK1/2 and NF-κB signal are essential signaling pathways that mediate a variety of
cellular processes, including cell survival, apoptosis, inflammation and angiogenesis …

Aim: Glycyrrhizin (GL) has been found to inhibit extracellular HMGB1 cytokine's activity, and
protect spinal cord, liver and brain against I/R-induced injury in experimental animals. The …

Objective To explore the possible protective effects and mechanisms of neutralizing
antibody of HMGB1 on hemorrhagic shock-induced cardiac injury in mice. Methods The KM …

Sepsis induced brain injury acts as an acute complication and accounts for deterioration and
high mortality rate of septic condition. HMGB1 is a late inflammatory mediator that plays a …

Objective To observe the levels of high mobility group box-1 protein (HMGB1), tumor
necrosis factor-alpha (TNF-α), IL-6, troponin I (Tn I) release in septic rats, and to explore …