唾液: 一种具有挑战性的体液, 用于诊断以阿尔茨海默病为重点的大脑疾病

C Zürcher, C Humpel - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
Biomarkers are molecules of biological processes that help in both the diagnosis of human
diseases and in follow-up assessments of therapeutic responses. Biomarkers can be …

[HTML][HTML] Saliva: a challenging human fluid to diagnose brain disorders with a focus on Alzheimer's disease

C Zürcher, C Humpel - Neural Regeneration Research, 2023 - journals.lww.com
Biomarkers are molecules of biological processes that help in both the diagnosis of human
diseases and in follow-up assessments of therapeutic responses. Biomarkers can be …

Salivary biomarkers in Alzheimer's disease

JL Andrews, F Fernandez - Diagnosis and Management in Dementia, 2020 - Elsevier
This chapter focuses on providing a brief overview of using saliva for the discovery of
potential biomarkers for the diagnosis of Alzheimer's disease (AD). In contrast to blood and …

Salivary biomarkers and neurodegenerative conditions

EA Thomas - … : Foundations of Interdisciplinary Saliva Research and …, 2020 - Springer
A major drawback for biomarker research on neurodegenerative diseases is that the
pathologically affected tissue, ie, the brain, cannot easily be accessed for sampling or …

[HTML][HTML] Saliva used as biological fluid to detect neurodegenerative and neurodevelopmental diseases

G Tartaglia, S Connelly - Frontiers in Neuroscience, 2023 - frontiersin.org
Neurodegenerative and neurodevelopmental diseases represent neurological disorders
that variably affect individuals and produce negative consequences, such as altered social …

Salivary biological biomarkers for Alzheimer's disease

D Liang, H Lu - Archives of Oral Biology, 2019 - Elsevier
Alzheimer's disease (AD) is becoming a threat to aging population all over the world. The
pathogenic process of AD is likely initiated many years before clinical onset, thus biomarkers …

Biomarkers for Alzheimer's disease in saliva: a systematic review

HS Gleerup, SG Hasselbalch, AH Simonsen - Disease markers, 2019 - Wiley Online Library
Background. The histopathological changes of Alzheimer's disease (AD) are detectable
decades prior to its clinical expression. However, there is a need for an early, inexpensive …

[HTML][HTML] Salivary biomarkers for Alzheimer's disease and related disorders

NJ Ashton, M Ide, H Zetterberg, K Blennow - Neurology and Therapy, 2019 - Springer
The search for accessible and cost-effective biomarkers to complement current
cerebrospinal fluid (CSF) and imaging biomarkers in the accurate detection of Alzheimer …

[HTML][HTML] Salivaomics as a potential tool for predicting Alzheimer's disease during the early stages of neurodegeneration

M François, A Karpe, JW Liu, D Beale… - Journal of …, 2021 - content.iospress.com
Background: The metabolomic and proteomic basis of mild cognitive impairment (MCI) and
Alzheimer's disease (AD) is poorly understood and the relationships between systemic …

[HTML][HTML] Salivary biomarkers: future approaches for early diagnosis of neurodegenerative diseases

G Schepici, S Silvestro, O Trubiani, P Bramanti… - Brain Sciences, 2020 - mdpi.com
Many neurological diseases are characterized by progressive neuronal degeneration. Early
diagnosis and new markers are necessary for prompt therapeutic intervention. Several …