Cerebrospinal fluid/plasma albumin ratio as a biomarker for blood-brain barrier impairment across neurodegenerative dementias

CS Musaeus, HS Gleerup, P Høgh… - Journal of …, 2020 - content.iospress.com
Background: Previous studies have shown an association between disruption of the blood-
brain-barrier (BBB) and dementias of different etiologies. The protein concentration of …

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

T Skillbäck, L Delsing, J Synnergren, N Mattsson… - Neurobiology of …, 2017 - Elsevier
A connection between dementias and blood-brain barrier (BBB) dysfunction has been
suggested, but previous studies have yielded conflicting results. We examined …

Increased albumin CSF/serum ratio in dementia with Lewy bodies

F Llorens, M Schmitz, SF Gloeckner, L Kaerst… - Journal of the …, 2015 - Elsevier
Background Alterations in the CSF/serum albumin ratio (Qalb) is currently recognized as
one of the most reliable markers of blood–brain barrier impairment and blood-CSF barrier …

[HTML][HTML] Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype

S Janelidze, J Hertze, K Nägga, K Nilsson… - Neurobiology of …, 2017 - Elsevier
Blood-brain barrier (BBB) dysfunction might be an important component of many
neurodegenerative disorders. In this study, we investigated its role in dementia using large …

Blood–brain barrier permeability is associated with different neuroinflammatory profiles in Alzheimer's disease

M Bruno, CG Bonomi, F Ricci… - European journal of …, 2024 - Wiley Online Library
Introduction Inflammation is an important player in Alzheimer's disease (AD), whose effects
can be influenced by the blood–brain barrier (BBB). Here, we investigated the relationship …

Blood-brain barrier permeability correlates with medial temporal lobe atrophy but not with amyloid-β protein transport across the blood-brain barrier in Alzheimer's …

Y Matsumoto, D Yanase… - Dementia and geriatric …, 2007 - karger.com
Abstract Background/Aims: Alterations in the blood-brain barrier (BBB) may play an
important role in the pathogenesis and treatment of Alzheimer's disease (AD). We …

Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease

S Chalbot, H Zetterberg, K Blennow… - Journal of …, 2011 - content.iospress.com
The role of blood-cerebrospinal fluid barrier (BCB) dysfunction in Alzheimer's disease (AD)
has been addressed but not yet established. We evaluated the BCB integrity in 179 samples …

[HTML][HTML] Alzheimer's disease pathology: pathways between chronic vascular risk factors and blood-brain barrier dysfunction in a cohort of patients with different types …

J Gan, X Yang, G Zhang, X Li, S Liu… - Frontiers in Aging …, 2023 - frontiersin.org
Background Blood brain barrier (BBB) breakdown is considered a potential mechanism of
dementia. The Alzheimer's disease (AD) biomarkers and vascular factors are also …

[HTML][HTML] Increased age and male sex are independently associated with higher frequency of blood–cerebrospinal fluid barrier dysfunction using the albumin quotient

M Castellazzi, A Morotti, C Tamborino, F Alessi… - Fluids and Barriers of …, 2020 - Springer
Background The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most
used biomarker for the evaluation of blood–cerebrospinal fluid barrier (B-CSF-B) …

Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers

L Hillmer, EB Erhardt, A Caprihan… - Journal of Cerebral …, 2023 - journals.sagepub.com
Blood-brain barrier (BBB) permeability can be measured by the ratio of albumin in
cerebrospinal fluid (CSF) and blood and by dynamic contrast-enhanced MRI (DCEMRI) …