Increased occurrence of age-associated disabilities and neurodegenerative diseases is the
price we pay for the tremendous elevation in life expectancy in our modern society. Aging …

Increased occurrence of age-associated disabilities and neurodegenerative diseases is the
price we pay for the tremendous elevation in life expectancy in our modern society. Aging …

Adult neurogenesis persists throughout life in the dentate gyrus (DG) of the hippocampus,
and its importance has been highlighted in hippocampus-dependent learning and memory …

Abstract Dnmt1, Dnmt3a and Dnmt3b are main genes encoding DNA methyltransferases
(Dnmts) which catalyze DNA methylation and regulate gene expression without changing …

Increased life expectancy in modern society comes at the cost of age-associated disabilities
and diseases. Aged brains not only show reduced excitability and plasticity, but also a …

Our memories define who we are. Normal aging is often accompanied by a decline in
memory functions leading to a condition known as age-related memory loss (ARML). With …

Alzheimer's disease (AD) is age‐related progressive neurological dysfunction. Limited
clinical benefits for current treatments indicate an urgent need for novel therapeutic …

Specific mutations within the replication foci targeting sequence (RFTS) domain of human
DNMT1 are causative of two types of adult-onset neurodegenerative diseases, HSAN1E and …

Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are
poorly understood. We found that aging was associated with a decrease in the expression of …

The transcriptional mechanisms that govern the development and plasticity of somatopic
sensory maps in the cerebral cortex have not been studied extensively. In particular, no …