We reviewed recent major clinical trials with investigational drugs for the treatment of
subjects with neurodegenerative diseases caused by inheritance of gene mutations or …

We reviewed recent major clinical trials with investigational drugs for the treatment of
subjects with neurodegenerative diseases caused by inheritance of gene mutations or …

The use of genetic screens to define cellular pathways that regulate neurodegenerative
disease proteins has emerged as a powerful strategy to identify potential therapeutic targets …

神经退行性疾病是医学研究领域中的一大难题, 近年来, 该类疾病遗传因素及病变机理的研究
取得了很大进展. 研究表明这类疾病的发生与某些基因突变后产生的蛋白有关 …

Why, with all the progress in the field of neurodegeneration, do we still lack disease-
modifying drugs that tackle the primary defect of severe cell loss? How much progress has …

Gene therapy is making a comeback. With its twin promise of targeting disease etiology and
'long-term correction', gene-based therapies (defined here as all forms of genome …

Neurodegenerative disorders (NDs) are a broad category of ailments caused by progressive
damage to cells and the nervous system that affect millions of individuals worldwide. The …

The pathogenesis of neurodegenerative diseases (NDDs) is complex and diverse. Over the
decades, our understanding of NDD has been limited to pathological features. However …

Neurodegenerative diseases (NDs), at least including Alzheimer's, Huntington's, and
Parkinson's diseases, have become the most dreaded maladies because there are no …

The identification of mutant genes responsible for inherited neurological disorders gives an
opportunity to consider new approaches to their treatment. Although replacement of …