Iron is essential for various cellular processes, but an excess of iron may cause organ
damage through the production of reactive oxygen species. Therefore, the amount of iron in …

Iron is an essential element, but because of its potential toxicity, free iron levels must be
tightly regulated. Regulation is mediated primarily via the duodenal cells and macrophages …

Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of
iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling …

Iron's primary role in mammalian biology is to bind oxygen in hemoglobin and myoglobin,
and to catalyze the enzymatic transfer of electrons by iron‐dependent enzymes, including …

Iron's primary role in mammalian biology is to bind oxygen in hemoglobin and myoglobin
and to catalyze the enzymatic transfer of electrons by iron‐dependent enzymes, including …

Iron is an essential trace nutrient, but its oxidized forms in the Earth's crust are poorly
bioaccessible. Humans and other mammals strictly conserve and recycle iron, so their iron …

Iron metabolism in mammals requires a complex and tightly regulated molecular network.
The classical view of iron metabolism has been challenged over the past ten years by the …

Iron is an essential metal for all living organisms. For example, iron is used in hemoglobin
synthesis. However, iron overload can cause serious organ damage. Therefore, iron …

The knowledge about mammalian iron metabolism has advanced dramatically over the past
decades. Studies of genetics, biochemistry and molecular biology allowed us the …

Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the
plasma iron concentrations in humans remain stable at 10–30μM. While most of the iron …